T淋巴瘤侵袭转移诱导因子在口腔鳞癌中的表达及临床意义被引量：1

Expression and clinical significance of T lymphoma invasion and metastasis inducing factor 1 in oral squamous cell carcinoma

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摘要目的 :T淋巴瘤侵袭转移诱导因子1(TIAM1)的高表达在多种人类恶性肿瘤中均有报道,但其在口腔鳞癌的表达却少有研究,本文旨在探讨TIAM1在口腔鳞癌中的表达及临床意义。方法:采用免疫组织化学法检测80例口腔鳞癌组织及20例正常口腔黏膜组织中TIAM1蛋白的表达情况,并分析相关的临床病理因素。采用SPSS19.0软件包对数据进行统计学分析。结果:TIAM1蛋白在口腔鳞癌组织中的阳性表达率(91.25%)显著高于正常口腔黏膜组织(10.00%);口腔鳞癌组织中TIAM1蛋白的表达与患者的性别、年龄无关,而与病理分级(P=0.019)、不同临床分期(P<0.001)、淋巴结转移(P=0.004)显著相关。结论 :TIAM1的表达与口腔鳞癌的发生、发展、转移密切相关。 PURPOSE： T lymphoma invasion and metastasis inducing factor 1 （TIAM1） overexpression has been reported in a variety of human cancers. However, the investigation of TIAM1 in oral squamous cell carcinoma （OSCC） was extremely rare. The aim of the study was to assess TIAM1 expression and explore its role in OSCC. METHODS： Immunohistochemistry staining was performed in 80 primary OSCC patients and 20 normal oral mucosa samples. The expression of TIAM1 and its association with clinicopathological parameters were analyzed using SPSS19.0 software package. RESULTS： TIAM1 expression was significantly stronger in OSCC tissues （91.25%） compared with normal oral mucosa （10.00%）; TIAM1 overexpression was significantly correlated with histological grade （P=0.019）, clinical stage （P〈 0.001） and lymph node metastasis （P=0.004）, but not significantly correlated with sex or age. CONCLUSIONS： TIAM1 may play an important role in the occurrence, development and metastasis of OSCC, which may be a potentially therapeutic target in the future.

作者林璐游镜民钱韵梅韩影熊浩峰苏彤

机构地区中南大学湘雅医院口腔医学中心口腔颌面外科湖南省常德市第一人民医院口腔科

出处《上海口腔医学》 CAS CSCD 2015年第5期569-573,共5页 Shanghai Journal of Stomatology

基金湖南省自然科学基金(2015JJ4048)~~

关键词 T淋巴瘤侵袭转移诱导因子口腔鳞癌免疫组织化学 T lymphoma invasion and metastasis 1 Oral squamous cell carcinoma Immunohistochemistry

分类号 R739.85 [医药卫生—肿瘤]

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