钙拮抗剂在心血管疾病中的作用机制及不良反应

Mechanism of calcium antagonists in treatment of cardiovascular disease and the occurrence of adverse reactions

目的：探讨钙拮抗剂在心血管疾病治疗过程中的作用机制及其不良反应发生情况。方法随机选取霍州煤电集团总医院2011年9月至2013年12月收治的采用钙拮抗剂进行治疗的心血管疾病患者129例，对患者的病史资料进行回顾性分析。结果本研究60例患者使用钙拮抗剂后出现不良反应，不良反应发生率为46．5％，其中以头痛发生率最高（51．7％），其次为外周组织水肿和面部潮红。结论钙拮抗剂是常用的心血管疾病治疗药物，临床应用时，应根据患者具体病情，结合药物性质和个体差异制定合理的用药方案，尽量避免长期大剂量用药，以降低不良反应的发生率。

Objective To investigate the mechanism of calcium antagonists in the treatment of cardiovascular disease and its adverse reactions.Methods From September 2011 to December 2013, 129 patients with cardiovascular disease adoptted calcium antagonists for treatment were chosen, the clini-cal data were retrospectively analyzed.Results For this study, a total of 60 cases had adverse reac-tions after use of calcium antagonists, the incidence of adverse reactions was 46.5%, with the high-est incidence of headache（51.7%） , followed by peripheral tissue edema and facial flushing.Con-clusions Calcium antagonists are commonly used in the treatment of cardiovascular disease.In clinical applications, the patient should be based on the specific condition, combined with the nature and individ-ual differences to develop a reasonable drug regimen, try to avoid long-term large doses of medication to reduce the incidence of adverse reactions.