急性等容稀释性自体输血在孕妇围生期的安全性

Safety of autologous blood transfusion of acute normovolemic hemodilution in the perinatal period of pregnantwomen

目的：研究孕妇围生期应用急性等容稀释性（ANH）自体输血的安全性。方法以新县人民医院2012年4月至2014年4月住院分娩的80例孕妇为研究对象，随机将其分为两组，对照组孕妇未行自体或异体输血，观察组孕妇则行急性等容稀释性自体输血，比较两组孕妇生产前后血红蛋白（ Hb）、红细胞压积极（ HCT）、红细胞计数（ RBC）、血小板计数（ PLT）指标及新生儿1、5 min Apgar评分情况。结果观察组孕妇生产前后Hb、HCT、RBC、PLT指标无明显变化（P＞0．05），对照组孕妇生产后Hb、HCT、RBC较生产前明显下降（P＜0．05）。两组孕妇生产后Hb[（111．90±11．77） g／L vs（101．41±15．76） g／L]、HCT[（34．79±4．17）％vs（30．55±4．27）％]、RBC [（3．72±0．80）＆#215;1012／L vs（3．38±0．37）＆#215;1012／L]比较差异有统计学意义（P＜0．05）。另外，两组孕妇分娩中出血量及新生儿1、5 min Apgar评分比较差异未见统计学意义（P＞0．05）。结论孕妇围生期行急性等容稀释性自体输血安全有效，值得临床研究应用。

Objective To study the safety of pregnant women who are adopting autologous blood transfusion of a-cute normovolemic hemodilution（ ANH） in the perinatal period.Methods From April 2012 to April 2014, 80 pregnant women in the people’ s hospital of Xinxian were chosen as the research objects, they were randomly divided into two groups, the patients in control group did not undergo autologous or allogeneic blood transfusion, the observation group was given autologous blood transfusion of acute normovolemic hemodilution, and then the indicators of Hb, HCT, RBC, PLT in pre-production and post-production, and the scores of 1 min, 5 min Apgar of newborns were compared.Results The indi-cators of Hb, HCT, RBC, PLT of the observation group in pre-production and post-production had no significant changes （ P＆gt;0.05）;compared with pre-production, the indicators of Hb, HCT, RBC of the control group in post-production sig-nificantly decreased（P〈0.05）.After production, the observation group’s indicators of Hb, HCT and RBC respectively were（111.90 ±11.77）g/L, （34.79 ±4.17）%and（3.72 ±0.80） ＆#215;1012/L; the control group’s indicators of Hb, HCT and RBC respectively were（101.41 ±15.76） g/L,（30.55 ±4.27）% and（3.38 ±0.37） ＆#215;1012/L, and the differences were significant （ P 〈0.05 ） . In addition, the differences of the amount of bleeding, the scores of 1 min, 5 min Apgar of newborns of the two groups had no＆amp;nbsp;significant difference（P〉0.05）.Conclusions It is safe that pregnant women in the perinatal period are given autologous blood transfusion of acute normovolemic hemodilution, and it is worthy of clinical application.