牡荆素对大鼠在体心肌缺血再灌注损伤的保护作用和部分机制

Protective effects of vitexin on vivo myocardial ischemia reperfusion injury in rats and part of the mechanism

目的：探讨牡荆素对大鼠在体心肌缺血再灌注损伤的保护作用，并对其部分作用机制。方法建立大鼠在体心肌缺血再灌注损伤动物模型，将其分为模型组、假手术组、葛根素组和牡荆素组，对各组大鼠模型的心肌梗死面积和相关血清标志物进行测定，并对结果进行分析对比。结果药物组大鼠心肌梗死面积均存在不同程度的降低，其中以牡荆素1．5 mg／kg组大鼠IS／AAR下降幅度最大，抑制率为28．71％。结论牡荆素能够有效降低大鼠在体心肌缺血再灌注损伤模型的心肌梗死面积，通过增强机体的抗氧化作用发挥其保护作用。

Objective To investigate the protective effect of vitexin on vivo myocardial ischemia reperfusion injury in rats, and the part of its mechanism of action.Methods The vivo myocardial ischemia-reperfusion injury in rats were es-tablished, which were divided into model group, sham operation group, puerarin group and vitexin group, myocardial infarct size and serum markers of rat model were measured, and the results were analyzed and compared.Results Myocardial in-farct size was reduced to varying degrees in drug groups, in which the largest decline of IS/AAR was the vitexin 1.5 mg/kg group, the inhibition rate was 28.71%.Conclusions Vitexin can effectively reduce the myocardial infarct size of vivo myo-cardial ischemia-reperfusion injury in rats, and exerts its protective effect by enhancing the body’s antioxidant effect.