糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期患者疗效观察

Curative effect observation of glucocorticoid combined with terbutaline in the treatment of patients with acute ex-acerbations of chronic obstructive pulmonary disease

目的：探讨慢性阻塞性肺疾病急性加重期采用糖皮质激素联合特布他林治疗的临床效果。方法选取2012年5月至2014年5月收治98例慢性阻塞性肺疾病急性加重期患者，随机分为特布他林治疗组（对照组）48例及糖皮质激素联合特布他林治疗组（观察组）50例，观察比较两组患者的临床效果。结果观察组治疗后临床总有效率为94％，对照组为77．1％，差异有统计学意义（P＜0．05）。两组治疗前动脉血氧分压（PaO2）、动脉血二氧化碳分压（ PaCO2）、pH值比较差异未见统计学意义（ P＞0．05），治疗均有改善；但观察组PaO2、PaCO2改善幅度优于对照组（P＜0．05），pH值比较差异未见统计学意义（P＞0．05）。结论慢性阻塞性肺疾病急性加重期采用糖皮质激素联合特布他林治疗，临床效果显著，具较高的安全性，对改善患者预后意义重大，值得临床广泛推广应用。

Objective To investigate the curative effect of glucocorticoid combined with terbutaline on patients with acute exacerbation of chronic obstructive pulmonary disease（ COPD） .Methods Ninrty-eight patients with acute ex-acerbation of COPD from May 2012 to May 2014 were selected, they were randomly divided into two groups： terbutaline treatment group（control group, n=48） and glucocorticoid combined with terbutaline treatment group（observation group, n=50）, the effects of the two groups were observed and compared.Results After treatment, the clinical total effective rate was 94%in observation group and 77.1% in control group, the difference was significant（P〈0.05）.Before treat-ment, PaO2, PaCO2, pH value had no significant difference between the two groups（P〉0.05）, and they were all im-proved after treatment, the improvement of PaO2 , PaCO2 in observation group was better than that in control group（ P〈0.05）, but the difference of pH value was not significant（P〉0.05）.Conclusions Glucocorticoid combined with ter-butaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease, the clinical effect is significant, with high security, can improve the prognosis of patients, so is worthy of wider application.