摘要
香草素受体4型瞬时感受器电位通道(transient receptor potential vanilloid 4 channel,TRPV4通道)是瞬时感受器电位通道家族成员之一。TRPV4通道是一种对钙离子具有选择通透性的阳离子通道,该通道激活后可以引起胞内钙离子浓度升高,进而参与调节机体多种生理或病理过程。现已证明,TRPV4通道可能在脑缺血再灌注所致的神经损伤中发挥重要作用。本文对近年来有关TRPV4通道与脑缺血再灌注损伤方面的研究进展予以综述。
Transient receptor potential vanilloid 4 （TRPV4） channel is a member of transient receptor potential superfamily. TRPV4 is selectively permeable to calcium. Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Especially, there is evidence showing that TRPV4 is involved in cerebral ischemic reperfusion injury. The present paper reviewed some research progress about the role of TRPV4 in cerebral ischemic reperfusion injury.
出处
《生理学报》
CAS
CSCD
北大核心
2015年第5期527-532,共6页
Acta Physiologica Sinica
基金
supported by grants from the University Students’ Innovative Entrepreneurial Training Project of Jiangsu Province,China(No.201410312026Z)
the National Natural Science Foundation of China(No.31271206)
Qinglan Project of Jiangsu Province,China(2014–2017)
关键词
TRPV4通道
钙离子
脑缺血再灌注
transient receptor potential vanilloid 4 channel
calcium
cerebral ischemic reperfusion
