摘要
Ⅳ型胶原蛋白作为肾脏基底膜中的支架结构,在维持肾脏滤过屏障中起着关键作用,其含量、分布和结构变化与肾脏疾病的发生发展密切相关。肾脏中IV型胶原蛋白的缺失和过度表达都将导致肾脏基底膜结构和功能异常,诱发或促进肾脏疾病的发生。因此,IV型胶原蛋白可能作为治疗靶点为临床肾脏疾病的控制提供新的策略。本文综述了IV型胶原蛋白在肾脏疾病中的作用。
Type Ⅳ collagen,scaffold structure of the kidney basement membranes,plays a key role in maintaining the kidney filtration barrier. The content,distribution and structural of type Ⅳ collagen are closely related to the occurrence and development of kidney disease. Overexpression and deletion of type Ⅳ collagen,which causes abnormal structure and function of kidney basement membranes,may induce or promote kidney disease. It will provide new strategies for the control of renal disease by targeting type Ⅳ collagen. This paper reviews the role of type Ⅳ collagen in renal disease.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2015年第9期1060-1065,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家重大新药创制"十二五"实施计划(2012ZX09303014-001)
湖南省自然科学基金项目(14JJ4006)
关键词
Ⅳ型胶原蛋白
基底膜
细胞外基质
肾脏疾病
Type Ⅳ collagen
basement membranes
extracellular matrix
renal disease
