硫酸镁联合拉贝洛尔与单用硫酸镁治疗妊娠高血压临床疗效分析

Clinical efficacy of magnesium sulfate combined with labetalol versus magnesium sulfate alone in treatment of pregnancy-induced hypertension: a comparative analysis

目的探讨硫酸镁联合拉贝洛尔与单用硫酸镁两种方案治疗妊娠高血压的临床效果。方法选取90例妊娠高血压患者按照治疗方法不同将其分成两组,每组45例,对照组采用硫酸镁静脉滴注治疗,观察组在对照组治疗的基础上联合拉贝洛尔进行治疗,观察两组治疗效果。结果观察组治疗总有效率明显高于对照组(88.9%vs 71.1%),胎心异常率、新生儿窒息率、产后出血率、终止妊娠率均低于对照组,收缩压和舒张压控制情况优于对照组,P<0.05,有统计学意义。结论硫酸镁联合拉贝洛尔用于治疗妊娠高血压与单用硫酸镁相比效果更加显著,值得临床推广。

Objective To investigate the clinical efficacy of magnesium sulfate combined with labetalol versus magnesium sulfate alone in the treatment of pregnancy-induced hypertension. Methods A total of 90 patients with pregnancy-induced hypertension were equally divided into control group treated with intravenous infusion of magnesium sulfate alone and observation group treated with intravenous infusion of magnesium sulfate combined with labetalol. The treatment outcomes of both groups were observed. Results The observation group had a significantly higher overall response rate than the control group（88.9% vs 71.1%）. Compared with the control group, the observation group had significantly lower rates of fetal arrhythmia, neonatal asphyxia, postpartum hemorrhage, and abortion（P 〈0.05）. The control of systolic and diastolic blood pressure in the observation group was significantly superior to that in the control group（P0.05）. Conclusion The efficacy of magnesium sulfate combined with labetalol is better than that of magnesium sulfate alone in the treatment of pregnancy-induced hypertension. This method holds promise for clinical application.