氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效及安全性分析

An analysis of efficacy and safety of clopidogrel plus aspirin in treatment of unstable angina

目的探究氯吡格雷联合阿司匹林在不稳定型心绞痛治疗中的效果及其安全性。方法选取我院于2014年2月到2015年2月收治的56例不稳定型心绞痛患者,将他们随机分为治疗组与对照组,每组各28例。在常规治疗的基础上,治疗组患者使用氯吡格雷药物联合阿司匹林进行治疗,对照组的患者单使用阿司匹林药物进行治疗,治疗时间为4周,治疗结束后对两组患者的治疗效果以及不良反应的发生情况。结果治疗组患者的总体治疗有效率为92.86%,对照组患者的总体治疗有效率为71.43%,治疗组明显高于对照组,P<0.05。另外,治疗组患者治疗前的全血粘度是(5.22±0.58)mpa/s,治疗后为(4.67±0.66)mpa/s,P<0.05。而对照组治疗前后的全血粘度为(5.33±0.70)mpa/s,比(5.17±0.61)mpa/s,P>0.05。两组患者不良反应,无差异P>0.05。结论不稳定型心绞痛患者使用氯吡格雷联合阿司匹林来治疗能够有效地提高治疗效果,不增加不良反应的发生,值得推广与应用。

Objective To investigate the efficacy and safety of clopidogrel plus aspirin in the treatment of unstable angina. Methods Fifty-six patients with unstable angina who were admitted to our hospital from February2014 to February 2015 were randomly and equally divided into treatment group and control group. On the basis of conventional therapy, patients in the treatment group were given clopidogrel plus aspirin for four weeks, while patients in the control group were given aspirin alone for four weeks. The treatment outcomes and adverse reactions were compared between the two groups after treatment. Results The overall response rate was significantly higher in the treatment group than in the control group（92.86% vs 71.43%, P 〈0.05）. Moreover, the whole blood viscosity in the treatment group was significantly reduced after treatment（5.22±0.58 vs 4.67±0.66 m Pa·s, P 〈0.05）, while there was no significant change in the whole blood viscosity in the control group after treatment（5.33±0.70 vs 5.17±0.61 m Pa·s, P 〉0.05）. There were no significant differences in adverse reactions between the two groups（P 〉0.05）. Conclusion Clopidogrel plus aspirin can effectively improve treatment outcomes and control the incidence of adverse reactions in patients with unstable angina,which holds promise for wide application.