胺碘酮与利多卡因治疗乌头碱中毒所致室性心律失常的疗效探讨

Therapeutic effects of amiodarone and lidocaine in treatment of ventricular arrhythmia caused by aconite poisoning

目的通过临床对比研究,观察胺碘酮和利多卡因治疗乌头碱中毒所致室性心律失常患者的临床疗效。方法研究对象选自2012年1月至2015年1月期间来我院接受治疗的乌头碱中毒所致室性心律失常患者,共68例。将68例患者采用单双号法平均分成胺碘酮组和利多卡因组,分别予以两组患者胺碘酮和利多卡因治疗。结果经治疗发现胺碘酮组患者相关临床症状的缓解时间明显早于利多卡因组患者(P<0.05),室性心率失常逆转时间为(38.9±6.2)min,室性心率失常消失时间为(91.6±11.2)min,与利多卡因组患者的(49.1±6.5)min和(113.5±15.4)min比较存在的差异具有统计学意义(P<0.05),两组患者均未发生严重药物不良反应。结论与利多卡因比较,胺碘酮治疗乌头碱中毒所致室性心律失常的临床效果更为显著,安全性高,可最为临床治疗乌头碱中毒所致室性心律失常患者的理想药物。

Objective To observe the clinical effects of amiodarone and lidocaine in the treatment of ventricular arrhythmia caused by aconite poisoning through a clinical comparative study. Methods A total of 68 patients with ventricular arrhythmia caused by aconite poisoning treated in this hospital from January 2012 to January 2015 were selected as study subjects and were equally divided into amiodarone group and lidocaine group according to odd and even numbers. The patients in these two groups were treated with amiodarone and lidocaine, respectively. Results Time to relief of related clinical symptoms in amiodarone group was significantly shorter than that in lidocaine group（P 〈0.05）.In the amiodarone group, time to reversion of ventricular arrhythmia was（ 38.9 ±6.2） min and time to disappearance of ventricular arrhythmia was（ 91.6±11.2） min, while in the lidocaine group, time to reversion of ventricular arrhythmia and time to disappearance of ventricular arrhythmia were（ 49.1±6.5） min and（ 113.5±15.4） min, respectively; the difference between the two groups had statistical significance（P 〈0.05）. No patient experienced severe adverse drug reactions.Conclusion Compared with lidocaine, amiodarone is more effective and safer in the treatment of ventricular arrhythmia caused by aconite poisoning and can be applied as an ideal drug for this disease in clinical practice.