左卡尼汀治疗慢性心力衰竭的疗效及对心功能的影响

L-carnitine in treatment of chronic heart failure: clinical efficacy and effect on cardiac function

目的探讨外源性左卡尼汀对慢性心力衰竭的疗效以及对心功能的影响。方法 106例慢性心衰患者被分为对照组和观察组。对照组给予常规治疗。观察组在常规治疗基础上给予左卡尼汀。比较分析两组治疗效果,观察两组患者治疗前后血浆B型钠尿肽(BNP)、左心室射血分数(LVEF)、心输出量(CO)、每搏输出量(SV)以及心脏指数(CI)。结果经治疗后,观察组疗效优于对照组,差异有统计学意义(P<0.05);观察组LVEF、C0、SV、CI较治疗前和对照组治疗后明显提高。结论补充左卡尼汀可提高CHF患者疗效,改善心功能。

Objective To investigate the clinical efficacy of exogenous L-carnitine in the treatment of chronic heart failure and its effect on cardiac function. Methods A total of 106 patients with chronic heart failure were divided into control group and observation group. The patients in the control group were treated with routine treatment and the patients in the observation group with L-carnitine in addition to the routine treatment. Comparison of clinical efficacy was made between the two groups and markers in the two groups were observed before and after the treatment, including serum B-type natriuretic peptide, left ventricular ejection fraction（LVEF）, cardiac output（CO）, stroke volume（SV）, and cardiac index（CI）. Results The observation group had a significantly better treatment outcome than the control group（P 〈0.05）; compared with those in the observation group before the treatment and the control group after the treatment, LVEF, CO,SV, and CI in the observation group after the treatment were significantly improved. Conclusion L-carnitine supplement can improve the treatment outcome and cardiac function in patients with chronic heart failure.