炎症体及相关蛋白在力诱导牙周炎症反应中的作用

The role of inflammasomes and related proteins in periodontal inflammation induced by mechanical forces

炎症体是一种多蛋白复合体,能介导IL-1β等多种炎症细胞因子释放,在炎症的发生发展中具有重要的作用。随着对炎症体研究的不断深入,目前已有文献报道炎症体可能参与机械力所诱导的机体炎症性疾病。与此同时,近年来研究显示,机械力可诱导牙周组织发生炎症反应,并伴随IL-1β和caspase-1/-5的表达。然而,炎症体及相关蛋白在力诱导牙周炎症反应中的作用尚不明确。综述炎症体的特点、在力相关炎症性疾病中的作用、机械力诱导的牙周炎症及其与炎症体和相关蛋白关系的研究进展。

Inflammasome is a kind of multi-protein complexes which can mediate the release of several inflamma- tory cytokines such as IL-1βand thus plays an important role in the occurrence and development of inflammation. Along with the progressive researches on inflammasomes, recent literature has reported that inflammasomes might participate in some inflammatory diseases induced by mechanical forces. Meanwhile, recent studies have shown that mechanical forces can induce inflammation in periodontium, with the expression of IL-1β and caspase- 1/-5. However, the role of inflammasomes and related proteins in periodontal inflammation has not been specified so far. In this article, the recent advances on characteristics of inflammasomes and their role in inflammatory diseases related to forces, as well as periodontal inflammation induced by mechanical forces and its relationship with inflammasomes and related proteins were reviewed.