CEACAM1在原发性乳腺癌组织中的表达

CEACAM1 expression in primary breast cancer tissue and the related clinical features

目的探讨CEACAM1在乳腺癌组织中的表达水平及临床特征。方法应用免疫组化和western blot法检测120例乳腺癌患者及40例乳腺良性病变患者组织中CEACAM1的表达水平,并对患者的年龄、肿瘤类型、肿瘤部位、ER/PR及淋巴结转移等临床因素进行相关性分析研究。结果 CEACAM1在乳腺癌组织中表达阳性率为85.0%,而在乳腺良性病变患者组织中表达阳性率为27.5%,乳腺良性组织的阳性表达率明显低于癌组织,两组之间表达阳性率差异有统计学意义(P<0.05)。CEACAM1的表达阳性率与患者年龄、肿瘤部位、肿瘤类型、淋巴结转移、ER/PR、临床分期及浸润深度均无相关关系(P>0.05)。结论 CEACAM1在乳腺癌组织中为高表达,但与患者的临床特征无关;CEACAM1视为促癌基因,对乳腺癌的发生发展有重要作用,并对判断乳腺癌的预后有潜在的价值。

Objective To study the expression level and significance of CEACAM1 in breast cancer tissue. Methods Using IHC and western blot to detect CEACAM1 expression level in 120 cases of breast cancer patients and 40 cases of breast benign lesions. The age, type and location of the cancer, ER/PR, and lymph node metastasis were analyzed. Results The positive expression rate of CEACAM1 was 85.0% in breast cancer tissue, while it was 27.5% in benign breast lesions. The positive rate in breast benign lesions was obviously lower than breast cancer tissue. The difference of positive rates between the two groups was statistically significant （P 〈 0.05）. The positive rate of CEACAM1 expression was not correlated with age, location and type of tumor, lymph node metastasis, ER/PR, clinical staging and infiltration depth （P 〉 0.05）. Conelusion CEACAM1 expression in breast cancer tissue is up-regulated, and has no correlation with clinical features. As a cancer-promoting gene, CEACAM1 plays an important role in the development of breast cancer and has potential value in evaluating the prognosis of breast cancer.