动态应答人工生物系统研究进展

Recent Progress in Dynamic Responding Synthetic Biological Systems

代谢和应答是生命的基本特征,自然界中的生命有机体的应答与调控是极度动态和时空精密的.复杂合成生物体系也应具有相应的应答调控特性.通过动态可控的元器件及人工调控系统,调控信息的流动使之对体内外环境动态应答,可用于对生命行为的理解与操纵.发展可与人体相互作用并动态应答的合成生物系统,也将为疾病的干预提供新的可能性.本文简要综述了近年来动态应答合成生物学器件与人工生物系统的研究进展.

Metabolism and responses are fundamental features of life. Such responses of living organisms are extremely dynamic and are regulated with spatiotemporal precision. Sophisticated synthetic biological systems should also possess corresponding response control characteristics. Building of dynamically controllable synthetic modules, devices, and artificial biological systems enables the regulation of the information stream and of dynamic responses to changes in the environment in vivo and in vitro, which will greatly help us understand and manipulate biological behaviors. Development of synthetic biological systems that interact with and dynamically respond to the organism provides new possibilities for disease intervention. This article briefly reviews the recent research progress of synthetic biological devices and artificial biological systems capable of dynamic response.