摘要
脂联蛋白(APN)是一种主要由脂肪细胞分泌的细胞因子,具有胰岛素增敏以及抗炎和抗动脉粥样硬化等多重作用。人的APN基因位于3q27点位上,约17 kb大小,在结构上与补体C1q和肿瘤坏死因子相似。总体而言,APN与骨代谢关系密切,一部分研究结果支持APN具有促进成骨、抑制破骨的功能,一部分研究则认为APN促进破骨、抑制成骨,Apn基因敲除小鼠的骨表型变化也不是十分明显。目前的研究结果说明,APN调控骨代谢的机制十分复杂,其促成骨或抑制成骨的作用可能与机体所处的状态有关,在不同的条件下,APN对骨代谢的调节可能具有多重性,然而其中的具体机制尚待进一步研究。
Adiponectin is the most abundant adipocyte-secreted adipokine. It regulates energy homeostasis and increases insulin sensitivity. Adiponectin is a multifunctional protein with anti-diabetic, anti-inflammatory, and anti-atherosclerotic properties. The effect of adiponectin on bone metabolism has been widely reported. However, its precise mechanism of action remains controversial and unclear. A few studies have demonstrated that adiponectin can significantly stimulate osteoblastic differentiation, promote osteogenesis, and inhibit bone resorption. Conversely, other studies have shown opposite effects. In addition, several clinical studies have reported that plasma adiponectin level is an independent predictor factor of bone mineral density. This paper reviews recent publications on adiponectin and bone metabolism.
出处
《国际口腔医学杂志》
CAS
北大核心
2015年第6期681-684,共4页
International Journal of Stomatology
基金
上海市自然科学基金青年项目(12ZR1448500)
上海市卫生局青年科研项目(20134y052)
关键词
脂联蛋白
骨代谢
骨密度
adiponectin
bone metabolism
bone mineral density
