维生素E对妊娠糖尿病患者CRP、IL-6、IL-8及脂类水平的影响

Effects of vitamin E on CRP,IL-6,IL-8 and lipid levels in patients with gestational diabetes mellitu

目的:观察维生素E对妊娠糖尿病(GDM)患者C反应蛋白(CRP)、白介素-6(IL-6)、白介素-8(IL-8)及脂类水平的影响。方法:将纳入研究的167例GDM患者抽签分为观察组(87例)和对照组(80例),对照组给予饮食、运动干预治疗,血糖控制不佳者给予胰岛素皮下注射控制血糖,观察组在对照组的基础上给予维生素E口服,30d后观察两组炎症指标CRP、IL-6、IL-8和脂类指标总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)的变化情况。结果:治疗后,两组CRP、IL-6、IL-8及TC、TG、LDL-C、HDL-C水平较本组治疗前均有改善,差异具有统计学意义(P<0.05),且观察组改善幅度更大,治疗后两组各指标水平比较,差异均有统计学意义(P<0.05)。结论:维生素E可抑制GDM时机体存在的炎症反应,并对脂类代谢具有调节作用,应有助于改善母婴结局。

Objective：To investigate the effects of Vitamin E on CRP,IL-6,IL-8and lipid levels in patients with gestational diabetes mellitus.Methods：167patients with GDM were randomly divided into observation group（n=87）and control group（n=80）.Patients in control group were intervened with diet,exercise therapy.If glycemic level was poorly controlled,then subcutaneous injections of insulin was applied to control blood sugar.After 30 days,observed changes of inflammatory markers including C-reactive protein（CRP）,interleukin 6（IL-6）,interleukin-8（IL-8））and lipid levels（including：total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL）,high density lipoprotein（HDL-C）.Results：After treatment,level of CRP,IL-6,IL-8and TC,TG,LDL-C,HDL-C were significantly improved comparing with that before treatment in both groups（P〈0.05）,and the improvement was more obvious in the observation group.After treatment,the above indexes in the observed group were improved more obviously than that of the control group,the difference was statistically significant（P〈0.05）.Conclusions：Vitamin E can inhibit the inflammatory reaction and regulate lipid metabolism level in patients with GDM,which might be favorable for maternal and infant outcomes.