不同生理期辨证治疗乳腺增生症临床研究

Clinical Research of Differentiating and Treating Different Physiological Stages of Breast Hyperplasia

目的：观察根据女性生理期采用中药乳腺一号方、乳腺二号方对乳腺增生症进行辨证论治的临床效果。方法：采用随机数字表法将本院2013年1月~2014年8月收治的120例乳腺增生症妇女分为观察组和对照组各60例,对照组采用常规治疗法,观察组在对照组基础上根据患者生理周期进行辨证论治（排卵后至月经期采用乳腺一号方,月经后至排卵前采用乳腺二号方）,比较两组患者治疗6周后的临床疗效差异。结果：治疗前观察组和对照组患者的E2、P、LH、PRL检测值比较差异不具有统计学意义（P〉0.05）;治疗后P、LH检测值较治疗前均显著升高（P〈0.05）;治疗观察组的P、LH值显著高于对照组患者（P〈0.05）。治疗后两组患者的中医症候积分较治疗前均显著的降低（P〈0.05）,观察组较对照组降低更加显著（P〈0.05）。治疗后两组患者的超声检查分级较治疗前均显著的好转（P〈0.05）,治疗后超声检查分级观察组较对照组效果更好（P〈0.05）。观察组临床治愈率高于对照组,显效率高于对照组,治疗后观察组的临床疗效分布显著的优于对照组患者（P〈0.05）。结论：根据女性生理期采用中药乳腺一号方、乳腺二号方对乳腺增生症进行辨证论治能偶取得更加显著的临床效果。

Objective： To observe the clinical effect of using breast No. 1,No. 2according to the female physiology period to differentiate and treat breast hyperplasia. Methods： 120 cases of mammary gland hyperplasia women in our hospital from2013 January to 2014 August were randomly divided into observation group and controlled group with 60 cases in each group,the controlled group with conventional therapy,the observation group used Chinese medicine according to the patient＇s physiological cycle was on the basis of the controlled group（ ovulation to menstruation using breast No. 1,after menstruation to ovulation with breast No. 2）,compared two groups of patients with clinical curative effect in the treatment of difference after 6weeks. Results：Before treatment,the observation group and the controlled group of patients with E2,P,LH,PRL detection value difference was not statistically significant（ P〈0. 05）; after treatment,P,LH detection value than before treatment were significantly increased（ P〈0. 05）; treatment observation group P,LH value was significantly higher than that of the controlled group patients（ P〈0. 05）. After treatment the symptom scores of the patients in the two groups were significantly decreased compared with those before treatment（ P〈0. 05）,the observation group than in the controlled group decreased more significantly（ P〈0. 05）. After treatment,ultrasound grading in patients of the two groups compared with those before treatment were significantly improved after treatment（ P〈0. 05）,ultrasound examination grading observation group than in the controlled group（ P〈0. 05） effect was better. The cure rate of the observation group was 56. 67% which was higher than that of the controlled group which was 43. 33%,markedly effective rate of the observation group was 30% which was higher than that of the controlled group which was 26. 67%,the clinical curative effect of distribution in the observation group after treatment was significantly better than the controlled group（ P〈0. 05）. Conclusion： The clinical effect is obvious according to the female physiology period using breast No. 1and breast No. 2in mammary gland hyperplasia.