高危型人乳头瘤病毒检测联合液基薄层细胞学检查筛查宫颈病变

Application of high-risk human papillomavirus test combined with thinprep cytology test in screening of cervical lesions

目的:评价高危型人乳头瘤病毒(HR-HPV)检测联合液基薄层细胞学检查(TCT)在早期筛查宫颈病变中的价值。方法:对1 652例妇科门诊患者行TCT检查,对其中192例结果为低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)及部分结果为未明确诊断意义的不典型鳞状上皮细胞(ASCUS)、无上皮内病变或恶性细胞(NILM)的患者同时行HR-HPV检测及阴道镜下宫颈多点活检。结果:192例患者中宫颈活检阳性率为72.4%,LSIL和HSIL者宫颈活检阳性率显著高于NILM和ASCUS者。随着病理学诊断级别升高,HR-HPV阳性率也升高。HR-HPV阳性者宫颈活检的阳性率明显高于阴性者。结论:HR-HPV检测联合TCT筛查宫颈病变简单、有效。

Objective： To assess the value of high-risk human papillomavirus（ HR-HPV） test combined with thinprep cytology test（ TCT） in early screening for cervical lesions. Methods： TCT was performed on 1 652 patients in clinic service of gynecology department. One hundred and ninty-two patients were chosen,including most of the patients with low-grade squamous intraepithelial lesion（ LSIL） and high-grade squamous intraepithelial lesion（ HSIL）,and some of the patients with atypical squamous cells of undetermined significance（ ASCUS） and negative for intraepithelial lesion or malignancy（ NILM）. HR-HPV test and multiphase biopsy under colposcopy were done. Results： The positive rate of cervical biopsy was 72. 4% in 192 patients. The positive rate of cervical biopsy in LSIL and HSIL patients was obviously higher than that in NILM and ASCUS patients. The positive rate of HR-HPV test increased with the severity of pathology increasing. The positive rate of cervical biopsy of HR-HPV positives was significantly higher than that of HR-HPV negtives. Conclusion： It is a simple and effective method for screening cervical lesions by HR-HPV test combined with TCT.