甲状腺功能异常对稳定性心绞痛患者发生心房颤动的影响

Association between thyroid dysfunction and incidence of atrial fibrillation in patients with stable angina

目的：观察甲状腺功能异常对稳定性心绞痛患者发生心房颤动（房颤）的影响。方法：纳入稳定性心绞痛患者617例为研究对象,根据患者血浆中促甲状腺激素（TSH）水平分成TSH〈0.55 m IU·L-1组、0.55~4.78 m IU·L-1组、〉4.78 m IU·L-1组。比较3组实验室检查的结果及各组房颤发生率。结果：617例稳定性心绞痛患者中,48例诊断为阵发性或持续性房颤,发生率为7.8%。房颤发生率TSH 0.55~4.78 m IU·L-1组最低,为6.3%（34/543）;TSH〉4.78 m IU·L-1组最高,为19.6%（9/46）,TSH〈0.55 m IU·L-1组为17.9%（5/28）,3组之间差异有统计学意义（P=0.001）。相关性分析结果显示,甲状腺功能异常与稳定性心绞痛患者发生房颤存在相关性。结论：甲状腺功能异常与稳定性心绞痛患者房颤的发生相关,对合并甲状腺功能异常的稳定性心绞痛患者应警惕和预防房颤的发生。

Objective： To explore the correlation between thyroid dysfunction and incidence of atrial fibrillation（ AF） in patients with stable angina. Methods： Six hundred and seventeen cases of stable angina were enrolled this research. According to TSH levels the patients were divided into 3 subgroups： 〈 0. 55 m IU ·L-1group,0. 55 ~4. 78 m IU·L-1group,〉 4. 78 m IU·L-1group. Laborlatery data and incidence of AF were compared among the three group. Results： A total of 48 patients were diagnosed as AF（ 7. 8%）. Incidence of AF in TSH 0. 55 ~ 4. 78 m IU· L-1group was the lowest（ 6. 3%,34 /543）; in TSH 〉 4. 78 m IU · L-1group was the highest（ 19. 6%,9 /46）,and in TSH 〈 0. 55 m IU · L-1group was 17. 9%（ 5 /28）,the difference among them was statistically significant（ P = 0. 001）. There was correlation between thyroid dysfunction and incidence of AF in patients with stable angina. Conclusion： Our results show correlation between thyroid dysfunction and incidence of AF in patients with stable angina. We should pay attention to preventing occurrence of AF in cases of stable angina with thyroid dysfunction.