乌司他丁治疗合并凝血功能障碍的危重症患者临床效果评价

Evaluation of the clinical effect of ulinastatin in treatment of critically ill patients with coagulation disorders

目的：探讨乌司他丁对合并凝血功能障碍危重症患者的临床效果。方法：将60例合并凝血功能障碍的危重患者随机分为对照组和观察组。对照组给予常规对症治疗;观察组在此基础上每次给予乌司他丁20万U静脉注射,每日1~3次,连续治疗1周。记录并比较两组患者入院时及治疗1周后血小板计数、凝血酶原时间、部分活化凝血酶原时间、D-D二聚体、APACHE评分和DIC评分。结果：治疗后血小板计数观察组明显高于治疗前和对照组治疗,凝血酶原时间、部分活化凝血酶原时间均明显短于治疗前和对照组治疗,血D-D二聚体含量明显低于治疗前和对照组治疗;治疗后观察组患者的APACHE评分和DIC评分明显低于治疗前和对照组,差异均有统计学意义（P〈0.05）。结论：乌司他丁可以明显改善危重患者的凝血功能障碍,降低患者的病情严重程度。

Objective： To investigate the clinical effect of ulinastatin in treatment of critically ill patients with coagulation disorders. Methods： Sixty critically ill patients with coagulation disorders were randomly divided into the control group and the observation group. The control group were given routine symptomatic treatment,the observation group were received ulinastatin（ intravenous injection of 20 million U,1-3 times one day） on the basis of the control group and continuous treatment for one week. The platelet count,prothrombin time,activated prothrombin time,D-D polymers,APACHE score and DIC score of patients at the day of admission and one week after treatment were compared. Results： The platelet count in the observation group after the treatment was both significantly higher than that before the treatment and the control group after the treatment. The prothrombin time and activated prothrombin time were both significantly less than those before the treatment and the control group after the treatment. The content of D-D polymers was both significantly less than that before the treatment and the control group after the treatment. The APACHE scores and DIC scores in the observation group after the treatment were both significantly less than those before the treatment and of the control group after the treatment,and there were all statistical significance differences（ P 〈 0. 05）. Conclusion： Critically ill patients with coagulation disorders treated by ulinastatin can significantly improve the coagulation function and reduce the severity of the patient’ s condition.