葡萄糖酸氯已定口腔护理液在ICU的应用效果

Efficacy observation of chlorhexidine gluconate oral nursing liquid in the application of ICU

目的：探讨葡萄糖酸氯已定口腔护理液在减少口臭、口腔黏膜炎症,预防呼吸机相关性肺炎（VAP）方面的临床疗效。方法：将320例ICU患者随机分为对照组和实验组,每组各160名。对照组采用0.9%无菌生理盐水、实验组采用0.28%~0.32%葡萄糖酸氯已定口腔护理液进行口腔护理。分别对两组患者的口臭、口腔黏膜炎症和VAP的发生情况进行评价。结果：实验组治疗后口臭及口腔黏膜炎症发生率均较治疗前明显降低（P〈0.01）,且明显低于对照组（P〈0.01）。VAP发生率实验组为20%（15/75）,对照组为28.8%（21/73）,两组差异无统计学意义（P〉0.05）。结论：葡萄糖酸氯已定口腔护理液应用于ICU的临床护理效果优于无菌生理盐水。

Objective： To investigate clinical efficacy of chlorhexidine gluconate oral nursing liquid in reducing oral malodor,oral inflammation,and preventing ventilator-associated pneumonia（ VAP）. Methods： Three hundred and twenty patients were randomly divided into control group and experimental group,with each 160. 0. 9% sterile physiological saline was used in control group,and 0. 28%-0. 32% chlorhexidine gluconate oral nursing liquid was used in experimental group for oral care. The oral malodor,oral inflammation and the incidence of VAP were evaluated separately. Results： After treatment,the incidence of oral malodor incidence and oral inflammation in experimental group were lower significantly（ P 〈 0. 01）,and also,it was lower significantly than those of the control group（ P 〈 0. 01）. The incidence of VAP was 20%（ 15 /75） in experimental group and 28. 8%（ 21 /73） in control group,the difference between the two groups had no statistically significance（ P 〉 0. 05）. Conclusions： Chlorhexidine gluconate oral nursing liquid for ICU clinical nursing efficacy is superior to sterile physiological saline.