肠道菌群失调与肠易激综合征关系的研究进展

Advances in relationship between regulation of intestinal flora imbalance and irritable bowel syndrome

肠易激综合征是人类发病率最高的功能性肠道疾病,其发病因素包括肠道菌群失调、小肠细菌过度生长、肠道动力异常、肠道高敏感、肠道分泌吸收功能异常、肠道屏障功能破坏、肠道黏膜免疫异常、脑肠轴异常等。现有研究发现上述致病机制可能都与肠道菌群失调相关,本文就此予以综述。

Irritable bowel syndrome is a kind of human functional bowel disease which has the highest incidence. Its risk factors include intestinal flora imbalance, intestinal bacterial overgrowth, intestinal motility disorders, visceral hypersensitivity, abnormal intestinal secretion and absorption, intestinal barrier function damage, abnormal gut immune, abnormal brain-gut axis. Existing studies have found that the above pathogenic mechanism may be related to the intestinal flora imbalance, which will be reviewed in this article.