Wnt/β-catenin信号转导通路与肺纤维化的关系

Relationship between Wnt/β-catenin transduction signaling pathway and pulmonary fibrosis

Wnt信号转导通路是与哺乳动物发育以及细胞分化、增殖密切相关的信号通路。经典Wnt通路中,β-连环蛋白为其下游的关键调控因子。众多研究表明,在肺纤维化的发生发展中,Wnt/β-catenin信号转导通路起着不可替代的调控作用。本文就Wnt/β-catenin信号转导通路与肺纤维化的关系及其研究进展做一综述,旨在探讨此通路在肺纤维化治疗中存在的潜在靶点。

Wnt signaling transduction pathway is closely related to the development of mammals and the differentiation and proliferation of cell. Beta serial protein is the key regulatory factor in the downstream of canonical Wnt pathways. Numerous studies have shown that Wnt/β- catenin signaling pathway plays an unsubstituted role during the occurrence and development of pulmonary fibrosis. This paper reviews the relationship between Wnt/beta-catenin signaling pathway and pulmonary fibrosis in hope of exploring the potential targets gene for anti-fibrosis treatment which exist in this pathway.