哺乳动物雷帕霉素靶蛋白复合体1在心肌缺血再灌注损伤中作用的研究进展

Advances in m TORC1 in myocardium ischemia/reperfusion injury

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,m TOR)是一种保守、非典型的丝氨酸/氨酸蛋白激酶,其主要通过复合体1(m TOR complex 1,m TORC1)和复合体2(m TOR complex 2,m TORC2)发挥作用。有研究证实,复合体1在心肌缺血期和再灌注期分别起到了不同的重要作用,通过调控复合体1可以影响细胞自噬水平、线粒体通透性转换孔的开放、抗氧化基因的上调等机制起到保护心肌的作用。本文对m TOR复合体的结构,以及m TORC1信号分别在心肌缺血期和再灌注期的作用机制进行综述。

The mammalian target of rapamycin （mTOR） is a conservative and atypical serine/threonine kinase which exerts its main functions through 2 different multi-protein complexes, named mTOR complex 1 （mTORC1） and mTOR complex 2 （mTORC2） respectively. Recent studies have demonstrated that mTORC1 plays a pivotal cardioprotective role in phase of myocardial ischemia as well as reperfusion through modulating autophagy, activation of mitochondrial permeability transition pore （mPTP） and upregulation of antioxidant genes. This article reviews the structure of roTOR complexes and the pivotal role of mTORC1 signaling during the injury process of myocardial ischemia and reperfusion respectively.