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多中心临床试验中心间样本不均衡的统计设计考虑 被引量:5

Statistical considerations on the unequal center sites in multicenter clinical trials
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摘要 针对国内新药在多中心临床试验中,采用区组统计病例收集后,出现的中心间样本不均衡的问题,本文回顾国外或国际指导原则中相应的意见或要求,阐述在估计总体治疗效应时存在的两种权重分析方法的区别及其合理应用。
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2015年第10期754-757,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 多中心研究 临床试验 均衡 检验功效 样本大小 权重分析 非权重分析 multicenter studies clinical trials balance power sample size weighted analysis unweighted analysis
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参考文献12

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