阿托伐他汀致肝功能异常的危险因素分析

Risk factors of hepatic dysfunction induced by atorvastatin

目的探讨阿托伐他汀致肝功能异常的危险因素,指导临床为患者提供药学监护,保证临床安全合理用药。方法选取2013年1月至12月在本院使用阿托伐他汀且资料完整的500例患者作为研究对象,对可能影响肝功能的诸多因素进行χ2检验、单因素分析和Cox多因素分析。结果肝功能异常的发生率为5.4%(27/500)。经单因素和多因素分析后显示,年龄≥60岁、饮酒≥500 g·周-1、合并用药(胺碘酮)与肝功能异常有关,是阿托伐他汀致肝功能异常的独立危险因素。结论老年人、饮酒和合并用药(胺碘酮)是阿托伐他汀致肝功能异常的危险因素,选用他汀类药物时应结合患者的个体情况,保证用药安全。

AIM To explore the risk factors of hepatic dysfunction induced by atorvastatin, to guide pharmaceutical care for patients, and to ensure medication safety. METHODS Totally 500 cases with use of atorvastatin and with complete data were selected in the research from January 2013 to December 2013 in our hospital. Univariate and Cox multivariate regression analysis was performed on the related factors of liver function. RESULTS The rate of hepatic dysfunction was 5.4%（ 27/500）. Univariate analysis and multivariate analysis revealed that age ≥ 60 years, drinking ≥ 500 g·week-1, drug combination（ amiodarone） were independent risk factors for atorvastatin induced hepatic dysfunction and may contributed to hepatic dysfunction.CONCLUSION The elderly, drinking ≥ 500 g·week-1, drug combination（amiodarone） are the risk factors for atorvastatin induced hepatic dysfunction. For medication safety of statins, patients＇ individual condition should be considered.