GA/HbA1c比值与2型糖尿病患者颈动脉粥样硬化斑块相关性被引量：4

Correlation of GA/HbA1c ratio with carotid atherosclerosis in type 2 diabetes

下载PDF

导出

摘要目的:评价GA/Hb A1c比值与2型糖尿病颈动脉粥样硬化斑块相关性。方法:选取四川省人民医院内分泌科住院的2型糖尿病患者,收集临床数据进行分析。结果:纳入154例患者,相关分析显示GA/Hb A1c比值与体质指数、血尿酸呈负相关;与年龄、同型半胱氨酸、空腹血糖、餐后血糖、左和右侧颈动脉中层厚度呈正相关。其中颈动脉斑块阳性组与阴性组相比,GA、GA/Hb A1c比值及同型半胱氨酸水平前者显著高于后者。Logistic回归分析显示GA/Hb A1c比值是影响2型糖尿病患者发生颈动脉粥样硬化斑块的独立危险因素(P=0.008)。结论:GA/Hb A1c比值与2型糖尿病患者颈动脉中层厚度呈正相关。这提示GA/Hb A1c比值能作为预测糖尿病患者心血管并发症的潜在临床指标。 Objective To investigate the association between the glycated albumin to glycated hemoglobin（GA / A1c） ratio and carotid plaque. Methods Type 2 diabetic（T2DM） patients in endocrine inpatient department of Sichuan Provincial People′s Hospital were chosen whose clinical data were collected. Results Of the recruited 154 T2 DM patients, GA / HbA1c ratio was negatively correlated with BMI, blood uric acid and was positively correlated with age, HCY, FBG, PBG, left carotid IMT and right carotid IMT. In terms of carotid plaque, GA, GA / HbA1c ratio and HCY were higher in carotid plaque positive patients than those without carotid plaque. The results of logistic regression analysis showed that GA / HbA1c ratio was significantly associated with the presence of carotid plaque（P=0.008）. Conclusions GA / HbA1c ratio was positively correlated with the presence of carotid artery IMT in T2 DM This suggests that GA / HbA1c ratio will serve as a useful clinical marker for predicting diabetic cardiovascular complications.

作者曹旭吴冀川李蓬秋张学军鲜杨包明晶杨艳邓君房俊

机构地区四川省人民医院内分泌科四川省人民医院检验科四川省人民医院中心实验室

出处《实用医学杂志》 CAS 北大核心 2015年第18期2969-2971,共3页 The Journal of Practical Medicine

基金四川省卫生厅课题项目(编号:110128)

关键词糖尿病 2型颈动脉中层厚度糖化血清白蛋白 GA/Hb A1c比值 Diabetes type 2 Carotid intima-media thickness Glycated albumin GA/HbA1c ratio

分类号 R587.2 [医药卫生—内分泌]

引文网络
相关文献

参考文献10

1Lee EY, Lee BW, Kim D, et al. Glycated albumin is a useful glycation index for monitoring fluctuating and poorly controlled type 2 diabetic patients [J]. Acta Diabetol, 2011, 48(2): 167-172.
2Lu L, Pu LJ, Zhang Q, et al decreased esRAGE levels are Increased glycated albumin and related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes [ J ]. Atherosclerosis, 2009,206 (2) : 540-555.
3Sato Y, Mago M, Asai A, et al. Association of glycated albumin with the presence of carotid plaque in patients with type 2 diabetes [J]. J Diabetes Investig, 2013,4(6):634- 639.
4Saisho Y, Tanaka K, Abe T, et al. Lower beta cell function relates to sustained higher glyeated albumin to glyeatcd hemoglobin ratio in Japanese patients with type 2 daibetes [J]. Endocr J, 2014,61(2) : 149-157.
5Rodino-Janeiro BK, Gonzalez-Peteiro M, Ucieda-Somoza R, et al. Glyeated albumin, a precursor of advanced glycation end- products, up-regulates NADPH oxidase and enhances oxidative stress in human endothelial cells: Molecular correlate of diabetic vasculopathy [J]. Diabetes Metab Res Rev,2010, 26 (7): 550-558.
6Kim KJ, Lee BW. The roles of glycated albumin as intermediate glycation index and pathogenic protein [J]. Diabetes Metab J , 2012,36(2) :98-107.
7Kishikawa H, Mine S, Kawahara C, et al. Glycated albumin and cross-linking of CD44 induce scavenger receptor expression and uptake of oxidized LDL in hunmn monoeytes [J]. Biochem Biophys Res Commuu, 2006, 339 (3) : 846-851.
8Moon JH, Chae MK, Kim KJ, et ah Decreased endothelial progenitor cells and increased serum glyeated albumin are independently correlated with plaque-forming carotid artery atheroselerosis in type 2 diabetes patients without documented ischemic disease[J]. Circ J, 2012,76(9) :2273-2279.
9Song SO, Kim KJ, Lee BW, et ah Serum glyeated albumin predicts the progression of carotid arterial atheroselerosis [J]. Atheroselerosis, 2012,225 (2) : 450-455.
10Hu Y, Liu W, Huang R, et al. Postchallenge plasma glucose excursions, carotid intima-media thickness, and risk factors for atherosclerosis in Chinese population with type 2 diabetes [J]. Atherosclerosis, 2010,210( 1 ) : 302-306.