FOXM1与Ki67共表达对三阴性乳腺癌患者预后的影响

Effect of FOXM1 and Ki67 co-expression on prognosis of patients with triple negative breast cancers

目的探讨癌基因叉头框蛋白M1(FOXM1)与增殖细胞Ki67抗原表达对三阴性乳腺癌(TNBC)患者预后的影响。方法免疫组化分析FOXM1和Ki67在60例TNBC组织中的表达,分析其表达量的相关性及其对TNBC患者预后的影响。结果 TNBC组织中FOXM1和Ki67共表达与肿瘤的大小、分化程度、TNM分期、腋窝淋巴结转移和血管神经侵犯密切相关(P<0.05或P<0.01)。FOXM1与Ki67表达呈正相关(r=0.4635,P<0.01)。FOXM1和Ki67高表达以及腋窝淋巴结转移情况可以作为判断TNBC预后的独立因素。结论TNBC组织高表达FOXM1和Ki67,有望成为TNBC患者预后判断的新指标,也为探索TNBC治疗新靶点提供思路。

Objective To investigate the effect of the expressions of forkhead box M1（FOXM1）and nuclear-associated antigen Ki67 on the prognosis of the patients with triple negative breast cancers（TNBC）.Methods The expressions of FOXM1 and Ki67in TNBC tissues were detected by immunohistochemistry in 60 TNBC cases.The correlation of FOXM1 and Ki67 expressions and their effect on the prognosis of TNBC patients were analyzed.Results The expressions of FOXM1 and Ki67in TNBC were closely related to tumour size,differentiation,TNM stage,axillary lymph node metastasis,vessel and/or nersis invasion（P〈0.05 or P〈0.01）.The expression of FOXM1 was positively correlated with that of Ki67（r=0.4635,P〈0.01）.The overexpressions of FOXM1 and Ki67 in TNBC and axillary lymph node metastasis were the independent factors for predicting the prognosis of TNBC patients.Conclusion The expressions of FOXM1 and Ki67in TNBC are higher,which could become the indicators for the prediction of the prognosis and new clue of exploring new therapeutic target for TNBC.