迟发性运动障碍患者血清胰岛素样生长因子-1的测定

The assay and clinical significance of serum Insulin-like growth factor-1 level in patients with tardive dyskinesia

目的探讨抗精神病药所致迟发性运动障碍(TD)患者体内胰岛素样生长因子-1(IGF-1)水平与TD的关系。方法采用酶联免疫吸附(ELISA)测定56例TD(TD组)、58例非TD(非TD组)慢性精神分裂症患者及58名正常人(对照组)血IGF-1水平。结果 TD组血IGF-1水平高于对照组(P<0.01)及非TD组(P<0.05),非TD组血IGF-1水平高于对照组(P<0.05),TD组、非TD组、对照组不同性别血IGF-1水平对比差异无显著性(P>0.05)。血IGF-1水平与TD患者的病情轻重无明显相关性(r=-0.29,P>0.05)。结论高血IGF-1水平可能是TD发病的危险因素,但其程度尚不是反映TD患者病情轻重的指标。

Objective To investigate the changes of serum Insulin-like growth factor-1 （IGF-1） in level in patients with tardive dyskinesia （TD） and their relationship with TD. Methods The serum levels of IGF-1 in schizophrenic patients with TD （ n = 56）, schizophrenic patients without TD （ non-TD, n = 58） and normal volun- teers （n=58） were assayed by ELISA. Results The serum level of IGF-1 in patients with TD was significantly higher than those in normal controls （P〈0. 01 ） and non-TD group （P〈0. 05） . The serum level of IGF-1 in pa- tients without TD was significantly higher than those in normal controls （P〈0. 05） . There was no significant gender difference of the serum IGF-I level in patients with TD, patients without TD and normal controls （P〉0. 05）. The correlation coefficients between the serum IGF-1 in level and total score of AIMS in patients with TD was -0. 29 （P 〉0. 05）. Conclusion IGF-1 may be involved in the pathophysiology of TD.