海洛因依赖患者戒断后血浆5-羟色胺水平的改变与焦虑、抑郁情绪的关系

Correlations between the change of plasma serotonin level, anxiety, and depression of heroin addicts after withdrawal

目的观察海洛因依赖患者戒断后血浆5-羟色胺(5-HT)水平及焦虑、抑郁情绪的变化,探索其戒断后焦虑、抑郁情绪与5-HT的关系。方法从强制隔离戒毒所招募53例海洛因依赖患者,进行为期26周的海洛因戒断,戒断前后采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评估其焦虑、抑郁状况,检测血浆5-HT、5-羟吲哚乙酸(5-HIAA)的质量浓度,并计算5-HT转化率。结果戒断26周后,海洛因依赖患者SAS得分明显下降(t=2.196,P<0.05),SDS得分无明显改变(t=1.127,P>0.05)。海洛因依赖患者血浆5-HT、5-HIAA水平均明显上升(t=-7.083,P<0.001;t=-4.316,P<0.001),5-HT转化率明显下降(t=4.026,P<0.001)。5-HT与SAS得分在基线及戒断26周时呈负相关(r=-0.28,P<0.05;r=-0.295,P<0.05),5-HT与SDS得分无相关性(P>0.05)。结论海洛因依赖患者戒断后焦虑情绪的缓解可能与血浆5-HT水平的升高有关。

Objective To observe the changes of 5-hydroxytryptamine （5-HT） level in the plasma, anxiety, and depression of heroin addicts after withdrawal and explore the correlations between 5-HT, anxiety, and depression after withdrawal. Methods A total of 53 heroin addicts were enrolled from a compulsory rehabilitation center and the withdrawal of heroin lasted for 26 weeks. Anxiety and depression symptoms were assessed by self-rating anxiety scale （SAS） and self-rating depression scale （SDS） before and after withdrawal. Plasma 5-HT and 5-hydroxyindoleacetic acid（5-HIAA）levels were detected and the 5-HT turnover rate was calculated. Results The SAS score of heroin addicts significantly decreased after 26 weeks of withdrawal （t=2. 196, P〈0.05） and the SDS score did not change remarkably （t=1. 127, P〉0.05）. The plasma 5-HT （ t= -7. 083, P〈0. 001） and 5-HIAA （ t= -4. 316, P〈0. 001） levels of heroin addicts significantly increased, while the 5-HT turnover rate significantly decreased （ t=4. 026, P〈0. 001）. The plasma 5-HT levels at baseline （ r= -0.28, P〈0.05） and after 26 weeks of withdrawal （ r= -0. 295, P〈0.05） negatively correlated with SAS scores at baseline and after 26 weeks of withdrawal. The plasma 5-HT level did not correlate with the SDS score （P〉0. 05）. Conclusion The relief of anxiety of heroin addicts after withdrawal may be relevant to the increase of plasma 5-HT level.