INSIG2基因与氯氮平相关代谢综合征的关联研究

Study on the correlation between INSIG2 and metabolic syndrome relevant to administration of clozapine

目的在中国汉族精神分裂症患者人群中,探讨INSIG2基因多态性与服用氯氮平相关代谢综合征的关系。方法入组621例服用氯氮平1年以上的精神分裂症患者,收集病史及临床资料,进行代谢指标测定。选择INSIG2基因的8个单核苷酸多态性(SNP)位点进行分型检测。所有数据以代谢综合征诊断标准进行分组,采用SPSS 17.0统计软件包及SHEsis软件进行统计分析。结果 621例服用氯氮平的精神分裂症患者出现代谢综合征的比例为41.8%。INSIG2基因rs17587100位点在校正相关临床资料后,其等位基因及基因型在组间的分布频率存在差异(P<0.05),但进行多重假设检验FDR校正后差异未见统计学意义(P>0.05)。结论本研究未发现INSIG2基因多态性与氯氮平相关的代谢综合征存在关联。

Objective To investigate the correlation between the polymorphism of insulin induced gene 2 （INSIGE） and metabolic syndrome （MetS） relevant to administration of clozapine for Han Chinese patients with schizophrenia. Methods Medical histories and clinical data of 621 schizophrenia patients treated with clozapine for at least one year were enrolled and metabolic indexes were measured. Eight single nudeotide polymorphisms （SNPs） of INSIG2 were genotyped. All data was grouped according to the criteria of metabolic syndrome and statistically analyzed by SPSS 17.0 and SHEsis. Results The incidence of MetS of 621 schizophrenia patients treated with clozapinc was 41.80/0. The allelic and genotypic frequencies of locus rs17587100 of INSIG2 between two groups were different after relevant clinical data was adjusted （P〈0.05）. However, the differences were not statistically significant after False Discovery Rate （FDR） correction of muhiple hypothesis testing （ P 〉 0.05 ）. Conclusion The polymorphism of IaVSIG2 doesn＇t correlate with MetS relevant to administration of clozapine.