社交恐怖症患者治疗前后表情刺激视觉P300的变化

Changes of visual P300 of patients with social phobia induced by facial expression stimuli before and after treatment

目的探讨社交恐怖症患者由表情刺激所诱发的视觉P300变异和疗效的关系。方法对40例社交恐怖症患者进行自编社会人口学资料表及李伯韦兹社交焦虑量表(LSAS)评估,并于治疗前及治疗后6个月进行由高兴、平静和厌恶3种表情刺激所诱发的视觉P300检测。结果治疗后患者的厌恶表情诱发P300波幅为(7.20±2.95)μV,低于治疗前的(9.55±4.35)μV(P<0.05);治疗前后LSAS评分变化值与厌恶表情诱发的P300波幅变化值之间呈正相关(P<0.01)。结论 P300波幅下降可能属于社交恐怖症的状态标志。

Objective To explore the correlation between visual P300 changes of patients with social phobia induced by facial expression stimuli and the therapeutic effect. Methods A total of 40 patients with social phobia were assessed by a self-designed demographic questionnaire and Liebowitz Social Anxiety Scale （LSAS）. The examination of visual P300 induced by three facial expression stimuli, i.e. happy, peace, and disgust, was conducted before treatment and 6 months after treatment. Results The P300 amplitudes （7.20 ±2.95） μV induced by disgust after treatment were lower than those （9.55 ±4.35） μV before treatment（P〈0.05）. The changes of LSAS scores positively correlated with the changes of P300 amplitudes induced by disgust （P〈0.01）. Conclusion The decrease of P300 amplitude may be a state sign of social phobia.