摘要
早泄(PE)是男性最为常见的性功能障碍疾病之一。而盐酸达泊西汀是目前唯一被芬兰和瑞典2009年批准用于治疗早泄的口服药物,现在已在包括中国在内的60多个国家和地区应用。它是一种强效选择性5-羟色胺再摄取抑制剂(SSRIs),其吸收快、起效快、半衰期短,支持按需服用。临床试验及应用表明,在各地区及不同人群中皆能有效延长PE患者的阴道内射精潜伏期(IELT),改善患者整体情况。与传统的SSRIs相比具有更好的安全性和耐受性,最常见的不良反应是恶心、腹泻、头痛、眩晕。严重不良事件罕见。总之,盐酸达泊西汀是一种有效,安全和耐受性良好的按需治疗早泄的药物。
Premature ejaculation（PE）is a most common sexual dysfunction,for which dapoxetine,a novel selective serotonin（5-HT）re-uptake inhibitor（SSRI）,is the only licensed oral medicine at present.With the advantages of fast absorption,rapid action,on-demand medication,and short half-life time,dapoxetine has been proved by clinical trials to be effective in prolonging the intravaginal ejaculation latency time（IELT）and improving the overall condition of PE patients in various areas and populations.Compared with the traditional SSRIs,dapoxetine has a better safety and tolerability.The most frequently reported dapoxetine-related adverse events include nausea,diarrhea,headache and dizziness,but with very few severe or serious cases.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2015年第10期931-936,共6页
National Journal of Andrology
关键词
早泄
盐酸达泊西汀
不良反应
premature ejaculation
dapoxetine
adverse event
