辽宁地区12307例女性宫颈高危型人乳头瘤病毒感染筛查结果分析

Screening results about cervical infection with high-risk HPV in 12,307 women of Northeast region of Liaoning Province

目的分析辽宁地区12 307例女性宫颈高危型人乳头瘤病毒(HPV)的筛查结果,了解该地区不同年龄段女性高危型HPV的感染。方法对2013年1月-2013年10月在中国医科大学附属第一医院妇科门诊自愿行宫颈病变筛查的12 307例女性行HPV筛查,HPV测定采用AB I2Prism7000 PCR检测仪,由专业妇科医师采用专用HPV取样器按严格规范方法采集标本,并于1周内完成检测。对不同年龄段女性的HPV检出率及感染亚型进行统计学分析。结果 1辽宁地区女性HPV的感染高峰年龄为≤30岁;2辽宁地区女性高危型HPV感染常见亚型(感染率>1%)由高到低依次为16、52、58、53、33、18及31;3HPV18感染高发于≤30岁女性;4高危型HPV单一亚型感染率随年龄的增加呈下降趋势;多重混合高危亚型的HPV感染率在≥60岁的老年组有所升高。结论辽宁地区不同年龄段女性高危型HPV感染具有特征性分布规律,针对性的进行宫颈癌筛查十分必要。

【Objective】 To analyze the screening results about the cervical infection with high-risk human papillomavirus HR-HPV in 12,307 women in the Northeast region of Liaoning Province, so as to investigate the infection condition and the clinic significance of HR-HPV testing in the screening of cervical lesions in this region. 【Methods】 From January 2013 to October 2013, 12,307 women were performed HPV DNA detection in the Gynecological Clinic of the First Affiliated Hospital of China Medical University. HPV DNA testing was performed with the ABI Prism 7000 PCR detector system by the gynecological doctors according to the strict specification method and all the tests were completed within 1 week. And HR-HPV detection rate and infection subtypes were compared between the women of different age. 【Results】 1 The peak age of HPV infection was ≤ 30 years. 2 The high rate subtypes（infection rate〉 1%） of HR-HPV detection were 16,52, 58, 53, 33, 18 and 31. 3 HPV 18 had a high infection rate in the women ≤ 30 years old. 4 With theincrease of age the single HPV infection rate was falling, but the HPV infection rate of multiple mixed subtypes had a rise in the elderly group ≥ 60 years. 【Conclusions】 Women of different age groups in Liaoning Province have their characteristic distributions of HR-HPV infection and it is necessary to perform the cervical cancer screening with a target.