针刺治疗青少年轻中度近视的随机对照试验

Randomized controlled trials of acupuncture for adolescents with mild-to-moderate myopia

目的：观察针刺治疗青少年轻中度近视的短期临床疗效。方法采用随机、平行、单中心、对照设计，对7～12岁轻中度近视患儿进行治疗观察。空白对照组予配戴单焦近视矫正眼镜不予其他任何干预治疗，试验组予配戴单焦近视矫正眼镜，并针刺双侧攒竹、瞳子髎、四白、目窗、合谷，针刺9 d停1 d，共治疗2个月。以屈光度为主要观察指标，眼轴、晶状体前后径及睫状体厚度为次要观察指标，观察治疗前后变化。结果共收集患儿81例（162只眼），试验组40例（80只眼），对照组41例（82只眼）。治疗后，试验组的等效球镜度、晶状体前后径、睫状体厚度较治疗前有统计学意义的降低（P＜0.05），眼轴的前后差异无统计学意义（P＞0.05）。对照组的晶状体前后径较治疗前增加（P＜0.05），等效球镜度、眼轴和睫状体厚度未见统计学意义的变化（P＞0.05）。2组间比较，除晶状体前后径的变化差异较明显外（P＜0.05），其他指标差异均无统计学意义（P＞0.05）。试验组所有患儿均未出现不良反应。结论针刺治疗青少年轻中度近视，可以使等效球镜度降低，减小晶状体前后径及睫状体厚度，并且具有较高的安全性。

OBJECTIVE To observe the short-term clinical treatment effect of acupuncture for adolescents with mild to moderate myopia. METHODS A randomized, parallel, single-center, controlled clinical trial was per-formed. A total of 81 teenagers, between seven and 12 years of age, with mild-to-moderate myopia were randomly assigned to two different groups （control and acupuncture groups ）. The subjects in both groups wore single-vision corrective lenses. In the acupuncture group, acupuncture was performed for nine consecutive days on five points （bi-lateral Cuanzhu, Tongziliao, Sibai, Muchuang, and Hegu ）, followed by no treatment for one day. Six cycles of treat-ment were undertaken continuously for a total of 60 days. The primary outcome was diopter. The secondary outcomes were included axial length, lens thickness, ciliary body thickness. The main time points for the evaluation of clinical efficacy were before and after treatment. RESULTS A total of 81 cases were collected （162 eyes）. The equivalent spherical, lens thickness and ciliary body thickness were significantly lower than that before treatment in the experi-mental group （P〈0.05）, but there was no significant difference of axial length in the experimental group （P〉0.05）;lens thickness was significantly thicker than that before treatment in the control group （P〈0.05）, and the equivalent spherical, axial length and ciliary body thickness were no significant difference in the control group （P〉0.05）. The equivalent spherical was significantly different between the groups （P〈0.05）, but other outcomes without significant changes （P〉0.05）. CONCLUSIONS Acupuncture treatment decreased diopter, lens thickness and ciliary body thickness in adolescents with mild to moderate myopia with higher safety.