胰腺黏液性囊性肿瘤临床特征汇集分析

A Pooled analysis on the clinical features of pancreatic mucinous cystic neoplasms

目的研究胰腺黏液性囊性肿瘤（MCN）的临床特征。方法运用汇集分析的方法，以PubMed为检索数据库，对2014年5月31日之前发表的关于胰腺MCN文献中经病理学证实的临床病例进行提取分析，主要包括患者的性别、年龄、主要临床表现、主要相关伴随疾病、肿瘤的形态学类型、解剖学分布特征、病理学类型等。结果共汇集文献184篇，病例2958例。胰腺MCN多发于中老年人群，女性发病率远高于男性；可发生于胰腺的各个部位，多位于胰腺体尾部；汇集的病例约3／4为良性；胰腺MCN的临床表现缺乏特异性，最常见症状为上腹部疼痛，其次为上腹部包块、体重减轻等症状，且有近1／3病例无明显症状。结论胰腺MCN缺乏特异性临床表现。在临床工作中应注意对胰腺MCN的诊断与鉴别，其治疗则需结合肿瘤的部位、局部特征及患者身体状况综合决定。

Objective To study the clinical features of pancreatic mucinous cystic neoplasm （MCN）. Methods Clinical cases with a positive histopathologic diagnosis of pancreatic MCN published before May 31st, 2014 in the PubMed database were studied. Results There were 184 articles on 2 958 of such cases. Pancreatic MCN was more prevalent in the middle-aged and elderly populations. The incidence was higher in female. Pancreatic MCN occurred in all parts of the pancreas, but the body and tail of the pan- creas were the more usual locations. Benign neoplasm accounted for nearly 3/4 of all the cases. The clinical manifestations of pancreatic MCN lacked specificity. The most common presentation was epigastric pain, fol- lowed by epigastric mass and weight loss. Nearly 1/3 of cases had no obvious manifestation. Conclusions The cfinical manifestations of pancreatic MCN lacked specificity. Awareness should be paid to its diagnosis. Tumor location, local characteristics and physical condition of the patient determine the therapy of this tumor.