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伴双重t(15;17)易位的四倍体急性髓系白血病一例并文献复习 被引量：1

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摘要 急性早幼粒细胞白血病（APL）是急性白血病中的一个特殊亚型，患者初诊时具有t（15；17）（q22；q21）易位，形成PML—RARer融合基因，是APL特有的细胞遗传学标志。与其他急性髓系白血病一样，多以伴有t（15；17）（q22；q21）易位的二倍体核型存在，伴有双重t（15；17）易位的四倍体核型比较少见，迄今报道仅有15例，多为亚洲人，
作者 郭福晓 李攀 陈红梅 夏成青 程建兵 邹媛 高娟
机构地区 杭州艾迪康医学检验中心有限公司 泸州医学院附属医院血液内科
出处 《中华临床医师杂志（电子版）》 CAS 2015年第18期115-118,共4页 Chinese Journal of Clinicians(Electronic Edition)
关键词 急性髓系白血病 四倍体 急性早幼粒细胞白血病 易位 文献复习 急性白血病 遗传学标志 特殊亚型
分类号 R733.71 [医药卫生—肿瘤]
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参考文献18

  • 1Kaito K,Otsubo H,Dobashi N,et al.CD2+tetraploid acute promyelocytic leukemia variant with double(15;17)translocations[J].Int J Hematol,2005,81(1):29-31.
  • 2Oh SH,Park TS,Kim HH,et al.Tetraploid acute promyelocytic leukemia with double t(15;17)and PML/RARA rearrangements detected by fluorescence in situ hybridization analysis[J].Cancer Genet Cytogenet,2003,145(1):49-53.
  • 3Morita Y,Takahashi A,Yamamoto K,et al.Secondary neartetraploidy with double der(15)t(15;17)in acute promyelocytic leukemia in relapse[J].Cancer Genet Cytogenet,2004,149(2):131-136.
  • 4Mohamed M,Dun K.Tetraploidy with double t(15;17)(q22;q21)in acute promyelocytic leukaemia[J].Pathology,2013,45(2):203-205.
  • 5Dalia SM,Horna P,Zhang L.Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA,a case report with review of literature[J].Int J Clin Exp Pathol,2014,7(8):5363-5368.
  • 6Matsouka P,Sambani C,Giannakoulas N,et al.Polyploidy in acute promyelocytic leukemia without the 15:17 translocation[J].Haematologica,2001,86(12):1312-1313.
  • 7Ravella PM,Liu D,Kojima K,et al.Acute promyelocytic leukemia with tetraploid karyotype:first report in the Western hemisphere and update of previous reports[J].Leuk Res,2011,35(12):e93-95.
  • 8樊一笋,沈霞,潘金兰,薛永权,尹栩芳.伴两个t（15;17）易位的四倍体核型急性早幼粒细胞性白血病的实验和临床研究[J].中华检验医学杂志,2010,33(6):522-526. 被引量：1
  • 9Au WY,Ma SK,Lam CC,et al.Tetraploid acute promyelocytic leukemia with large bizarre blast cell morphology[J].Cancer Genet Cytogenet,1999,115(1):52-55.
  • 10Kojima K,Imaoka M,Noguchi T,et al.Hypocellular acute promyelocytic leukemia with a tetraploid clone characterized by two t(15;17)[J].Cancer Genet Cytogenet,2003,145(2):169-171.

二级参考文献14

  • 1Clarke MR,Lynch EF,Contis LC,et al.Near-tetrploidy in adult acute myelogenous leukemia.Cancer Genct Cytogenet,1996,86:107-115.
  • 2Béné MC,Castoldi G,Derolf A,et al.Near-tetraploid acute myeloid leukemias:an EGIL retrospective study of 25 cases.Leukemia,2006,20:725-728.
  • 3Xue Y,He J,Wang Y,et al.Secondary near-pentaploidy and near-tetraploidy characterized by duplication of 8 ;21 translocation in the M2 subtype of acute myeloid leukemia,Int J Hematol,2000,71:359-365.
  • 4Au WY,Ma SK,Lain CC,et al.Tetraploid acute promyelocytic leukemia with large bizarre blast cell morphology.Cancer Genct Cytogenet,1999,115:52-55.
  • 5Kojima K,lmaoka M,Noguchi T,et al.Hypocellular acute promyelocytic leukemia with a tetraploid clone characterized by two t(15 ; 17).Cancer Genet Cytogenet,2003,145:169-171.
  • 6Oh SH,Park TS,Kim HH,et al.Tetraploid acute promyelecytic leukemia with double t(15 ; 17) and PML/RARα rearrangements detected by fluorescence in situ hybridization analysis.Cancer Genet Cytogenet,2003,145:49-53.
  • 7Morita Y,Takhashi A,Yamamoto K,et al.Secondary neartetraploidy with double der (15) t (15 ; 17) in acute promyelocytic leukemia in replase.Cancer Genet Cytogenet,2004,149:131-136.
  • 8Kuyama J,Tsumofi Y,Aoyama K,et al.Tetraploid acute promyeloeyticleukemiawithdoublePML/BARAgene rearrangements successfully treated with all-trans retinoic acid.Int J Hematol,2004,79:405-406.
  • 9Kaito K,Otsubo H,Dobashi N,et al.CD2 + tetraploid acute promyelocytic leukemia variant with double (15; 17)translocations.Int J Hematol,2005,81:29-31.
  • 10Chen S,Xue Y,Zhang X,et al.A new human acute monocytic leukemia cell line SHI-1 with t(6; 11) (q27;q23),p.53 geue alterations and high tumorigenicity in nude mice.Haematologica,2005,90:766-775.

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中华临床医师杂志（电子版）
2015年 第18期

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