自拟葛车饮治疗婴幼儿轮状病毒肠炎的临床观察

Clinical Observation of Self-made Geche Decoction for Treating Infantile Rotavirus Enteritis

目的观察自拟葛车饮治疗婴幼儿轮状病毒肠炎的临床疗效。方法 90例患儿随机分为常规用药组(甲组),利巴韦林组(乙组)和葛车饮组(丙组),每组30例。甲组口服葡萄糖酸锌片和口服补液盐Ⅲ;乙组在甲组的基础上加静脉滴注利巴韦林;丙组在甲组的基础上加口服葛车饮,均用7天。结果治疗后,丙组的总有效率为90.0%,乙组为60.0%,甲组为63.3%,总有效率丙组与甲、乙两组比较,差异均有统计学意义(P<0.05);治疗7天后,丙组轮状病毒转阴率为83.3%,乙组为56.7%,甲组为43.3%,转阴率丙组与甲、乙两组比较,差异均有统计学意义(P<0.05)。结论葛车饮能有效缓解轮状病毒肠炎患儿临床症状及体征,加快轮状病毒的转阴,是中医药治疗该病的一种有效药物。

Objective To observe the clinical effect of self-made Geche decoction for the treatment of infantile rotavirus enteritis （IRE）. Methods All 90 patients are randomly divided into three groups, Routine medication group （group A）, ribavirin group （group B） and Geche decoction group （group C）, 30 cases in each group. Group A was given zinc gluconate tablets and oral rehydration salts Ⅲ （ORS Ⅲ） everyday. Group B was based on group A to plus ribavirin injection. Group C was based on group A to plus Geche decoction. All of the groups were given 7 days treatment. Results The total effective rate was 63.3% in group A, 60.0% in group B and 90.0% in group C, respectively, showing significant difference （P〈0.05） in comparing group C with group A and B. After 6 days of treatment, the negative conversion rate of rotavirus was 43.3% in group A, 56.7% in hroup B and 83.3% in group C, respectively, which was higher in group A than group A and B （P 〈0.05）. Conclusion Self-made Geche decoction could effectively alleviate the clinical symptoms and signs in IRE patients, accelerate the negative conversion of rotavirus. So it is an effective drug for IRE in treatment TCM.