基于ICP-MS的金银花和山银花中20种重金属及微量元素分析

Determination of 20 Heavy Metals and Trace Elements in Lonicera Japonica and Lonicera Hypoglauca by ICP-MS

目的：建立金银花和山银花两种药材中 Pb、Cu、As、Cd、Hg、Mn、Ni、Tl 等20种元素含量测定方法。方法样品经微波消解后，以 Ge，In 两种元素作为内标，电感耦合等离子体质谱仪进行分析。结果各元素的线性关系良好；方法检出限为0.004μg·L-1~0.071μg·L-1；精密度和准确度良好；回收率在80%～100%的范围内。结论测量方法灵敏度高，专属性好，可为两种药材鉴别以及质量控制提供参考。

Objective To develop a method for the determination of a total of 20 elements such as plumbum （Pb）, copper （Cu）, arsenic （As）, cadmium （Cd）, mercury （Hg）, manganese （Mn）, nickel （Ni）, thalliu （Tl） in Lonicera japonica and Lonicera hypoglauca. Methods The samples were digested by microwave-assisted method and then chose appropriate determination parameters of ICP-MS, using Ge and In as the internal standard. Results All the correlation coefficients exceeded 0.9993, showing good linearities over the concentration range. The lower limit of detection of the assay ranged from 0.004 to 0.071 μg·L-1. The method exhibited good precision and accuracy, while the recoveries ranged from 80% to 100%. Conclusion The method is simple, accurate and highly sensitive, successfully applied to rapid monitoring the multi-elements in Lonicera japonica and Lonicera hypoglauca for the quality control and identification.