去甲氧柔红霉素联合半量预激方案对老年急性髓性白血病的效果研究

Treatment of idarubicin combined with half-dose pre-excitation scheme for elderly patients with acute myeloid leukemia

目的:探讨去甲氧柔红霉素联合半量预激方案对老年急性髓性白血病的效果。方法:老年急性髓性白血病患者80例根据随机抽签法分为治疗组与对照组各40例,治疗组选择去甲氧柔红霉素联合半量预激方案治疗,对照组选择柔红霉素联合半量预激方案治疗。结果:化疗后治疗组与对照组的总有效率分别为82.5%和62.5%,治疗组的总有效率明显高于对照组(P<0.05)。治疗组化疗期间的胃肠道反应、脱发、口腔溃疡、出血、感染等不良反应发生情况明显少于对照组(P<0.05),所有不良反应经对症处理后好转。随访至今,治疗组的生存期和无病生存期都明显高于对照组(P<0.05)。结论:去甲氧柔红霉素联合半量预激方案治疗老年急性髓性白血病能有效提高治疗总有效率,减少化疗不良反应的发生,从而促进患者生存时间的延长。

Objective：To investigate the effect of idarubicin combined with half-dose pre-excitation scheme on elderly patients with acute myeloid leukemia.Methods：Eighty elderly patients with acute myeloid leukemia were randomly divided into treatment group（n=40）and control group（n=40）.The patients in treatment group were treated with idarubicin combined with half-dose pre-excitation scheme,and the patients in control group were treated with daunorubicin combined with half-dose pre-excitation scheme.Results：The total effective rates after chemotherapy in treatment group and the control group were82.5% and 62.5%（P〈0.05）.The incidence rates of adverse reactions including gastrointestinal reaction,hair loss,mouth ulcer bleeding and infection during chemotherapy in treatment group were significantly lower than those in control group（P〈0.05）,and all adverse reactions were improved after treatment.The survival time and disease-free survival time in treatment group were significantly longer than those in control group（P〈0.05）.Conclusion：The idarubicin combined with half-dose pre-excitation scheme can improve the efficiency for elderly patients with acute myeloid leukemia,reduce the incidence of chemotherapy adverse reactions,and prolong the survival time.