老年精神分裂症顽固性幻听重复经颅磁刺激治疗的疗效分析

Efficacy of repetitive transcranial magnetic stimulation in the treatment of refractory auditory hallucinations in elderly patients with schizophrenia

目的:研究重复经颅磁刺激(rTMS)治疗老年精神分裂症(SZ)伴顽固性幻听的临床疗效。方法:收集我院收治的老年SZ伴顽固性幻听患者64例,随机分为观察组与对照组,每组32例。对照组予以利培酮治疗,观察组在对照组的基础上加用rTMS治疗,对比两组的疗效。结果:治疗后观察组的PANSS阳性症状、一般精神病理、幻听及总评分均明显低于对照组(P<0.05),两组的阴性症状评分无明显差异(P>0.05);观察组的AHRS及CFI评分均显著低于对照组(P<0.05);两组的不良反应比较无明显差异(P>0.05)。结论:rTMS治疗老年SZ患者伴顽固性幻听能够有效改善患者的精神分裂症状与幻听症状,且副作用较少,值得推广应用。

Objective：To investigate the clinical efficacy of repetitive transcranial magnetic stimulation（rTMS）in the treatment of refractory auditory hallucinations in elderly patients with schizophrenia（SZ）.Methods：Sixty-four elderly SZ patients with refractory auditory hallucinations in our hospital were selected and were randomly divided into observation group and control group,32 cases in each group.The control group received risperidone while the observation group received rTMS and risperidone.The clinical efficacy were compared between the two groups.Results：After the treatment,the scores of PANSS positive symptoms,general psychopathology,hallucinations and total scores were significantly lower in observation group than those in the control group（P〈0.05）.There were no significant differences in scores of negative symptoms between the two groups（P〉0.05）.The scores of AHRS and CFI were significantly lower in observation group than those in the control group（P〈0.05）.There were no significant differences in adverse events between the two groups（P〉0.05）.Conclusion：rTMS can alleviate symptoms of SZ and auditory hallucinations with fewer side effects,and should be widely applied in the treatment of auditory hallucinations in elderly patients with SZ.