喷雾干燥制备角鲨烯微胶囊的研究

Study of Squalene Microcapsule by Spray Drying Technology

以明胶、阿拉伯胶和麦芽糊精复配作为壁材,蔗糖酯和聚氧乙烯脱水山梨醇单油酸酯(吐温-80)为乳化剂,采用超声波乳化-均质-喷雾干燥工艺制备角鲨烯微胶囊产品。对超声波乳化工艺、壁材配比、乳化剂添加量以及喷雾干燥等参数进行了研究,并将优化工艺所制备的产品与冷冻干燥法制备微胶囊进行比较。结果表明,产品的最佳工艺为:角鲨烯3.0 g,吐温-80为0.6 g,经超声波乳化后(功率240 W,时间4 min)与明胶2.0 g,阿拉伯胶2.0 g,麦芽糊精10.0 g,蔗糖酯0.5 g,按料液固体质量分数为3.88%的比例与水混合,在进风温度180℃,出风温度105℃,喷雾空气流速为1.5 m3/h,进料速率为6 m L/min的条件下进行喷雾干燥。此条件下,角鲨烯微胶囊包埋率92.3%,颗粒呈球形,粒径在12.0μm左右。喷雾干燥相较于冷冻干燥,所得微胶囊包埋率更高,产品颗粒呈球形,粒径更小,热性能也更加稳定。

The microcapsule of squalene was carried out by ultrasonic-assisted emulsion,homogenization and spray drying using mixture of gelatin,arabic gum,maltodetrin as wall material,sucrose ester and tween-80 as emulsifier. The conditions of ultrasonic-assisted emulsion, ratio of wall materials, emulsifier amount and spray drying parameters were studied. The microcapsules produced respectively by spray drying and freezing drying were compared in this paper. The optimum process was showed as squalene 3. 0 g and tween-80 0. 6 g were emulsified under 240 W for 4 min,and then mixed with water as solid content3. 88% with gelatin 2. 0 g,arabic gum 2. 0 g,maltodetrin 10. 0 g,sucrose ester 0. 5 g; the inlet and outlet temperatures for spray drying were 180 ℃ and 105 ℃; and the spray air speed was 1. 5 m3/ h and feeding rate was 6 m L / min. Under these conditions,the encapsulation efficiency was 92. 3% and the microcapsule was nearly spherical,the mean size was about 12. 0 μm.Microencapsulated products by spray drying had higher encapsulation efficiency,smaller particle size and higher reliability compared with the products by freeze drying.