维吾尔族和汉族人群血清视黄醇结合蛋白4与非酒精性脂肪肝病的关联分析

Association between serum retinol-binding protein 4 and non-alcoholic fatty liver disease in Uyghur and Han ethnicities

目的分析维吾尔族、汉族人群血清视黄醇结合蛋白4(RBP4)在非酒精性脂肪肝病(NAFLD)患者中的水平,探讨血清RBP4与NAFLD的相关性。方法采用病例-对照研究的方法选择维吾尔族、汉族NAFLD患者各200名为病例组,维吾尔族、汉族健康者各200名为对照组,检测体重指数(BMI)、血压、生化指标以及血清RBP4浓度。采用Spearman相关分析,分析RBP4与NAFLD发生率的相关性;采用Pearson相关分析,研究RBP4与BMI、收缩压(SBP)、收缩压(DBP)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血尿酸(SUA)、谷草转氨酶(AST)、丙氨酸氨基转移酶(ALT)的相关性,采用非条件logistic回归分析NAFLD的影响因素。结果维吾尔族、汉族人群NAFLD组RBP4浓度显著高于对照组(P<0.01),NAFLD组维吾尔族RBP4浓度显著高于汉族(P<0.01)。两个民族RBP4水平与NAFLD发病率均呈正相关(P<0.001);维吾尔族人群RBP4浓度与BMI、FPG、TG、HDL、SUA、AST及ALT呈正相关性,汉族人群RBP4浓度与BMI、FPG、血压、TG、TC、HDL、SUA、AST以及ALT呈正相关性,非条件logistic回归分析显示维吾尔族人群、汉族人群中RBP4浓度为NAFLD的危险因素。结论维吾尔族、汉族人群NAFLD患者血清RBP4水平明显升高,血清RBP4水平与NAFLD患病相关,是NAFLD的危险因素之一。

Objective To investigate the levels of retinol - binding protein 4 （RBP4） in patients of Uyghur or Han ethnicities and with non-alcoholic fatty liver disease （NAFLD）, and to explore the relationship between serum RBP4 and NAFLD. Methods A case- control study was performed in 400 patients of NAFLD group （including 200 Uyghurs and 200 Hans） and 400 healthy controls （including 200 Uyghurs and 200 Hans）. Body mass index （BMI）, blood pressure, biochemical indicators and serum RBP4 concentration were determined. Spearman correlation analysis was conducted to explore the correlation between RBP4 and NAFLD. Pearson correlation analysis was used to analyze the correlation between RBP4 and BMI, systolic blood pres- sure （SBP）, diastolic blo：~t pressure （DBP）, fasting plasma glucose （FPG）, triglyceride （TG）, total cholesterol （TC）, high- density lipoprotein （HDL）, low- density lipoprotein （LDL）, serum uric acid （SUA）, aspartate transarninase （AST） as well as alanine transaminase （ALT）. The factors influencing NAFLD were analyzed by non- conditional logistic regression analysis. Results Serum RBP4 levels in the NAFLD group were significantly higher than those in the control group （P 〈 0.01）, and se- rum RBP4 levels of 200 Uyghurs were significantly higher than those of 200 Hans in the NAFLD group （ P 〈 0.01 ）. Serum RBP4 levels of Uyghur and Han ethnicities were both positively correlated with the incdences of NAFLD. Serum RBP4 levels of the Uyghurs were positively correlated with BMI, FPG, TG, HDL, SUA, AST and ALT, while serum RBP4 levels of the Hans were positively correlated with BMI, FPG, blood pressure, TG, TC, HDL, SUA, AST and ALT. Non - conditional logistic regression analysis showed that RBP4 was the risk factor for NAFLD in Uyghur and Han ethnicities. Conclusions Serum RBP4 levels of NAFLD patients of Uyghur and Han ethnicities are significantly increased. Serum RBP4 level is associated with the incidence of NAFLD, and it is one of the risk factors for NAFLD.