益肾填髓通络方在改善精亏髓减型帕金森患者的临床观察

Comparative Analysis of Herbal Paste of Tonifying Kidney and Filling Marrow and Relaxing Vein in Improving Symptoms of Patients with Parkinson's Disease

目的:探讨益肾填髓通络方改善帕金森病患者运动及非运动症状临床疗效。方法:入选50例精亏髓减证帕金森受试者按1:1比例分配到试验组(n=25)和对照组(n=25)中,对照组给予西医基础治疗;试验组给予益肾填髓通络方+西医基础治疗组,在入组时,3个月,6个月时对两组进行UPDRSI,II,III,IV部分及H-Y分级标准评级,非运动症状改善率,PD中医证候量化分级评分及临床有效率方面进行对比分析。结果:中西医治疗两组在不同时间UPDRS I,Ⅱ,Ⅳ(异动症及其他并发症),H-Y分级评分,腹张、便秘、疲乏改善,中医证候量化分级评分方面有显著差异。结论:益肾填髓通络膏方在改善帕金森UPDRS I,Ⅱ,Ⅳ(异动症及其他并发症)及非运动症状方面如腹胀,便秘,疲乏有一定功效,但与单纯西药治疗相比,中西医结合治疗在半年的治疗期内对患者的UPDRSIII及IV(波动现象)及睡眠障碍及排尿困难方面未体现明显优势。益肾填髓通络方在改善患者中医证候方面均显著优于对照组。

Objective： To investigate the clinical curative effect of Tonifying Kidney and Filling Marrow and Relaxing Vein recipe to improve the non motor symptoms and motor syndromes of patients with Parkinson＇s disease. Methods： 50 Parkinson subjects according to the proportion of 1： 1 were divided into the experimental group（ n = 25） and control group（ n = 25）. The control group was given the basic treatment of Western medicine and the experimental group was given Tonifying Kidney and Filling Marrow and Relaxing Vein recipe and western medicine treatment. 3 and 6 months after treatment,UPDRS I,II,III,IV and H- Y rating of were evaluated. Two groups＇ non motor symptom improvement rate,PD Chinese medicine syndromes of quantitative grading and clinical efficiency were compared and analyzed. Results： For the traditional Chinese medicine and Western medicine treatment of the two groups in different time points,UPDRS I,II,IV（ dyskinesia and other complications）,H- Y grading,abdominal Zang,constipation and fatigue improvement had significant differences. Conclusion： Tonifying Kidney and Filling Marrow and Relaxing Vein recipe in the improvement of Parkinson UPDRS I,II,IV（ dyskinesia and other complications） and non motorsymptoms such as bloating,constipation,fatigue have certain effect. But compared with the pure western medicine treatment,the treatment of UPDRS III and IV on the patients in the first half period of treatment with integrated traditional Chinese and Western medicine（ fluctuation phenomenon） on sleep disorder and micturition did not reflect the obvious advantages. Tonifying Kidney and Filling Marrow and Relaxing Vein recipe was significantly better than the control group to improve the syndromes of traditional Chinese medicine.