期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

利什曼原虫减毒活疫苗研究进展 被引量：1

Advances in the research of Leishmania live attenuated vaccine
下载PDF
导出
摘要 利什曼原虫减毒活疫苗因其保留了大部分免疫原性,能感染巨噬细胞,诱发与自然感染类似的免疫应答而受到众多科学家的青睐。本文综述了近年来减毒活疫苗的研究进展。 Leishmania live attenuated vaccines remain the most of parasitic immunogenecity and can enter into the macrophage that is similar to natural infection,which have interested many researchers. This paper reviews the study of the newest attenuated strains.
作者 刘鹏 敬保迁
机构地区 川北医学院免疫学与分子生物学研究所
出处 《川北医学院学报》 CAS 2015年第5期590-594,共5页 Journal of North Sichuan Medical College
基金 国家自然科学基金(30872213)
关键词 利什曼病 基因减毒活疫苗 理化减毒 Leishmaniasis Genetic live attenuated vaccine Physicochemical attenuation
分类号 R382.22 [医药卫生—医学寄生虫学]
  • 相关文献

参考文献2

二级参考文献19

  • 1Chang KP, McGwire BS. Molecular determinants and regulation of Leishmania virulence[J]. Kenetoplastid Biol Dis, 2002, 1(1): 1-7.
  • 2Chang KP, Reed SG, McGwire BS, et al. Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity[J]. Acta Trop, 2003, 85(3): 375-390.
  • 3Zhang K, Barron T, Turco SJ, et al. The LPG1 gene family of Leishmania major[J]. Mol Biochem Parasitol, 2004, 136(1): 11- 23.
  • 4Spath GF, Lye LF, Segawa H, et al. Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies[J]. Infect Immun, 2004, 72(6): 3622-3627.
  • 5Garami A, Ilg T. Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability[J]. EMBO J, 2001, 20(14): 3657-3666.
  • 6Jardim A, Hanson S, Ullman B, et al. Cloning and structurefunction analysis of the Leishmania donovani kinetoplastid membrane protein-11[J]. Biochem J, 1995, 305(Pt 1): 315-320.
  • 7Spath GF, Garraway LA, Turco SJ, et al. The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts[J]. Proc Natl Acad Sci USA, 2003, 100(16) : 9536-9541.
  • 8Piania A, Ilgb T, Elefantya AG, et al. Leishmania major proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function[J]. Microb Infect,1999, 1(8): 589-599.
  • 9Alce TM, Gokool S, McGhie D, et al. Expression of hydrophilic surface proteins in infective stages of Leishmania donovani[J]. Mol Biochem Parasitol, 1999, 102(1): 191-196.
  • 10Descoteaux A. Leishmania cysteine proteinases: virulence factors in quest of a function[J]. Parasitol Today, 1998, 14(6): 220-221.

共引文献5

同被引文献12

  • 1Chappuis F,Sundar S,Hailu A,et al.Visceral leishmaniasis:whatare the needs for diagnosis,treatment and control[J].Nat Rev Microbial,2007,5(ll):873-882.
  • 2Joshi S,Rawat N,Yadav N K,et al.Visceral leishmaniasis: advancementsin vaccine development via classical and molecular approaches [J]-Front Immunol,2014,5:380.doi:10.3389/f.
  • 3Peacock C SSeeger KHarris D,et al.Comparative genomic analysis of three Leishmania species that cause diverse human disease[J]. Nat Genet,2007,39(7):839-847.
  • 4Larsen MV, Lundegaard C,Lamberth K,et al.Large-scale validationof methods for cytotoxic T-lymphocyte epitope prediction [J].BMC Bioinformatics,2007,8:424.
  • 5Stranzl T,Larsen MV,Lundegaard C,et al.NetCTLpan-Pan-specific specific MHC class I epitope predictions [J].Immunogenetics,2010,62(6):357-368.
  • 6Horton P,Park KJ,Obayashi T,et al.WoLF PSORT:protein localization predictor[J].Nucleic Acids Res.2007,35:W585-7.
  • 7Duthie MS,Raman VS,Piazza FM,et al.The development and clinical evaluation of second-generation leishmaniasis vaccines[J].Vaccine,2012,30(2):134-141.
  • 8Kamhwi S,oliveiar F,Valenzuela JG.Using humans to make a human leishmaniasis vaccine [J].Sci Transl Med,2014,6(234):234fs8.
  • 9Stober CB,Lange UG,Roberts MT,et al.From genome to vaccinesfor leishmaniasis:screening 100 novel vaccine candidates against murine Leishmania major infection [J].Vaccine,2006,24(14):2602-2616.
  • 10Das S,Freier A,Boussoffara T,et al.Moduler multiantigen T cell epitope-enriched DNA vaccine against human leishmaniasis[J].Sci Transl Med,2014,6(234):234ra56.

引证文献1

二级引证文献3

川北医学院学报
2015年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部