血清胱抑素C与小动脉闭塞型卒中的关系

Relationship between serum cystatin C(Cys-C) and small artery occlusion(SAO)

目的:探讨胱抑素C(cystatin C,Cys-C)与小动脉闭塞型卒中(small artery occlusion,SAO)之间的关系。方法:选择首次发病的SAO患者作为观察组,同期门诊经头颅MRI检查无急性卒中患者作为对照组。采用单因素及Logistic回归分析Cys-C是否为构成SAO的独立预测因素;分析Cys-C与腔隙性梗塞灶及脑白质疏松严重程度的相关性。结果:共纳入SAO患者90例,对照组患者60例。观察组血清Cys-C水平高于对照组,差异有统计学意义(P<0.05);排除干扰因素后,血清CysC升高仍是SAO发生的独立预测因素(P<0.05);相关分析显示,血清Cys-C水平与腔隙性梗塞灶及脑白质疏松的严重程度呈正相关(P<0.05,r=0.226;P<0.05,r=0.214)。结论:血清Cys-C是SAO发生的独立预测因素,与腔隙性梗塞灶及脑白质疏松的严重程度呈正相关,对评估脑小血管病变有一定价值。

Objective： To explore the relationship between serum cystatin C（ Cys-C） and small artery occlusion（ SAO）. Methods： SAO patients with initial attack were selected as observation group,and those diagnosed with non-acute stoke according to head magnetic resonance imaging（ MRI） examination at the same period were selected as control group. Univariate and logistic regression analysis was used to analyze whether Cys-C was an independent predictive factor for SAO and the relationship between Cys-C and lacunar infarct nidi and leukoaraiosis severity. Results： A total of 90 patients were included in observation group and 60 in control group. Observation group was evidently higher than control group in serum Cys-C,and there was significant difference（ P〈0. 05）. After interference factors were excluded,serum Cys-C increase was still the independent predictive factor for the development of SAO（ P〈0. 05）. And relevance analysis showed that serum Cys-C level was in positive relation with lacunar infarct nidi and leukoaraiosis severity（ P〈0. 05,r = 0. 226; P〈0. 05,r = 0. 214）. Conclusion： Serum Cys-C is the independent predictive factor for the development of SAO and is in positive association with lacunar infarct nidi and leukoaraiosis severity,thus becoming valuable in evaluating small vessel disease.