动态血糖监测系统联合胰岛素泵持续皮下输注胰岛素治疗难治性糖尿病的效果及安全性研究

Effect and safety study of continuous glucose monitoring system combined with continuous subcutaneous insulin infusion in the treatment of refractory diabetes

目的：探讨动态血糖监测系统联合胰岛素泵持续皮下输注胰岛素治疗难治性糖尿病的效果及安全性。方法选取2012年10月~2014年11月本院收治的40例难治性糖尿病患者作为研究对象，随机分成观察组和对照组，各20例。观察组采用动态血糖监测系统联合胰岛素泵持续皮下输注胰岛素治疗，对照组采用每日多次胰岛素皮下注射治疗（MDI），比较两组的效果及安全性。结果观察组的治疗总有效率为95.0%，显著高于对照组的80.0%，差异有统计学意义（P〈0.05）。观察组的胰岛素用量、低血糖发生次数、血糖波动幅度显著少于对照组，差异有统计学意义（P〈0.05）。观察组的血糖达标时间显著短于对照组，差异有统计学意义（P〈0.05）。观察组治疗后的血糖水平显著低于对照组，差异有统计学意义（P〈0.05）。结论对难治性糖尿病患者采用动态血糖监测系统联合胰岛素泵持续皮下输注胰岛素治疗，安全性及有效性优于MDI，值得临床推广应用。

Objective To explore the efficacy and safety of continuous glucose monitoring system （CGMS） combined with continuous subcutaneous insulin infusion （CSII） in the treatment of refractory diabetes. Methods 40 patients with re-fractory diabetes in our hospital from October 2012 to November 2014 were selected and randomly divided into the ob-servation group and the control group,with 20 patients in each group.The observation group was treated with CGMS combined with CSII,the control group was given multiple daily injection of insulin （MDI）.The effect and safety in two groups was compared. Results The total effective treatment rate in the observation group was 95.0%,which was higher than 80.0%in the control group,with significant difference （P〈0.05）.The amount of insulin,the frequency of hypoglycemia and the fluctuation of blood glucose in the observation group was less than that in the control group,with significant differ-ence （P〈0.05）.The standard time of blood glucose in the observation group was shorter than that in the control group, with significant difference （P〈0.05）.The level of blood glucose after treatment in the observation group was lower than that in the control group,with significant difference （P〈0.05）. Conclusion For the patients with refractory diabetes,CGMS com-bined with CSII has better safety and effectiveness than MDI,it is worthy of promotion and application.