多沙普仑与右美托咪定预防全身麻醉下食管癌根治术后寒战反应的效果分析

Effect analysis of doxapram and dexmedetomide in the prevention of postoperation chill of esophageal cancer treated with radical surgery under general anesthesia

目的：探讨多沙普仑与右美托咪定预防全身麻醉下食管癌根治术后寒战反应的效果。方法选取2012年1月~2014年12月在本院就诊并决定进行食管癌根治术的102例患者作为研究对象，随机分为对照组、多沙普仑组和右美托咪定组，各34例。所有患者均采用食管癌根治术，对照组在手术完成后迅速静脉注射生理盐水，多沙普仑组在手术完成后迅速静脉注射盐酸多沙普仑注射液，右美托咪定组在完成气管插管后静脉泵入右美托咪定。比较3组的术后寒战发生率、发生时间和持续时间。结果多沙普仑组与右美托咪定组的寒战发生率显著低于对照组，差异有统计学意义（P〈0.05）。多沙普仑组与右美托咪定组的寒战出现时间显著长于对照组，差异有统计学意义（P〈0.05）。多沙普仑组与右美托咪定组的寒战持续时间显著短于对照组，差异有统计学意义（P〈0.05）。多沙普仑组与右美托咪定组的寒战发生率、发生时间和持续时间比较，差异无统计学意义（P〉0.05）。结论多沙普仑和右美托咪定在预防全身麻醉下食管癌根治术后的寒战反应中具有良好效果，但两者在预防效果上的差别需进一步研究。

Objective To explore the effect of doxapram and dexmedetomide in the prevention of postoperation chill of esophageal cancer treated with radical surgery under general anesthesia. Methods 102 cases with esophageal cancer accepted radical surgery from January 2012 to December 2014 in our hoapital were selected and randomly divided into the control group,the doxapram group and the dexmedetomide group,34 cases in each group.All patients were treated with radical resection of esophageal carcinoma.The control group was given the physiological saline after the surgery,the doxapram group was given doxapram hydrochloride injection by intravenous injection rapidly,the dexmedetomide group was given dexmedetomide by intravenous pumping after completing tracheal intubation.The incidence rate of postopera-tive chill,occurrence time and the duration time among three groups was compared. Results The incidence rate of post-operative chill in the doxapram group and the dexmedetomide group was lower than that in the control group,with sig-nificant difference （P〈0.05）.The occurrence time in the doxapram group and the dexmedetomide group was longer than that in the control group,with significant difference （P〈0.05）.The duration time in the doxapram group and the dexmedetomide group was shorter than that in the control group,with significant difference （P〈0.05）.There was no sig-nificant difference in the incidence rate of postoperative chill,occurrence time and the duration time between the doxapram group and the dexmedetomide （P〉0.05）. Conclusion The effect of doxapram and dexmedetomide in the pre-vention of the postoperation chill of esophageal cancer treated with radical surgery under general anesthesia are both good,but the differences between them need further study.