咪唑斯汀治疗荨麻疹并发过敏性鼻炎的临床效果分析

Analysis clinical effect of mizolastine in treatment of urticaria and allergic rhinitis

目的：分析咪唑斯汀治疗荨麻疹并发过敏性鼻炎的临床疗效。方法选取2013年3月～2014年8月在我院就诊的75例荨麻疹并发过敏性鼻炎患者，按照治疗方式分为治疗组（40例）和对照组（35例），治疗组采取咪唑斯汀治疗，对照组采取西替利嗪治疗，对比两组的治疗效果。结果治疗组的临床治疗总有效率为90.0%，显著高于对照组的74.3%（P〈0.05）。治疗后，治疗组荨麻疹、过敏性鼻炎症状评分显著低于对照组，荨麻疹、过敏性鼻炎症状改善起效时间显著短于对照组（P〈0.05）。两组患者治疗后均未出现肝肾功能异常，仅个别患者出现轻微的头晕、嗜睡、口干，均未影响治疗；两组的不良反应发生率差异无统计学意义（P〉0.05），但治疗组的复发率高于对照组（P〈0.05）。结论咪唑斯汀治疗荨麻疹并发过敏性鼻炎的效果显著，具有较高的治疗安全性。

Objective To analysis the clinical effect of mizolastine in treatment of urticaria and allergic rhinitis. Meth-ods 75 patients with urticaria and allergic rhinitis in our hospital from March 2013 to August 2014 were selected.They-were divided into treatment group （n=40） and control group （n=35） according to different therapy measures.The treat-ment group was given mizolastine,the control was given cetirizine.The therapy effect was compared between two groups. Results The total efficient rate in treatment group was 90.0%,which was higher than 74.3%of control group（P〈0.05）.Af-ter treatment,the symptom scores of urticaria and allergic rhinitis in treatment group were significantly lower than those of control group,urticaria and allergic rhinitis symptoms improved onset time in treatment group were significantly short-er than those of control group（P〈0.05）.No patient appeared liver and kidney dysfunction before and after treatment.Only individual patients appeared dizziness, drowsiness and dry mouth,the symptoms were mild and did no impact the treat-ment. There was no difference in adverse event between two groups （P〉0.05）,but the difference of recurrence in two groups was significant （P〈0.05）. Conclusion Mizolastine has significant effect in treating urticaria and allergic rhinitis, and has higher security.