美沙拉嗪联合双歧三联活菌治疗溃疡性结肠炎的效果观察

Effect observation of mesalazine combined with dichotomous sanlian living bacterium in the treatment of ulcerative colitis

目的：分析美沙拉嗪联合双歧三联活菌治疗溃疡性结肠炎（UC）的临床效果。方法选取2013年1月～2014年1月我院收治的96例UC患者作为研究对象，采用随机数字表法分为对照1组（n=32）、对照2组（n=32）和观察组（n=32），对照1组采用美沙拉嗪治疗，对照2组采用双歧三联活菌治疗，观察组采用美沙拉嗪联合双歧三联活菌治疗，对三组患者的临床治疗效果进行观察和分析。结果观察组的治疗总有效率为90.63%，不良反应发生率为6.25%；对照1组的治疗总有效率为71.88%，不良反应发生率为31.25%；对照2组的治疗总有效率为75.00%，不良反应发生率为25.00%，三组差异有统计学意义（P〈0.05）。结论对UC患者采用美沙拉嗪与双歧三联活菌联合治疗，能明显改善患者的临床症状，减少不良反应，疗效显著，从而提高患者的生活质量，值得临床推广应用。

Objective To analyze the clinical effects of mesalazine combined with dichotomous sanlian living bacterium in the treatment of ulcerative colitis（UC）. Methods 96 patients with UC admitted into our hospital from January 2013 to January 2014 were selected as research objects.They were divided into control group 1,control group 2 and observation group by random number table,with 32 cases in each group.In the control group 1 was treated with mesalazine,control group 2 was treated with dichotomous sanlian living bacterium,observation group was treated with mesalazine combined with dichotomous sanlian living bacterium.The treatment effects in 3 groups were compared and analyzed. Results The effective rate in observation group was 90.63%,the adverse reactions occurred rate was 6.25%.The effective rate in con-trol group 1 was 71.88%,the adverse reactions occurred rate was 31.25%.The effective rate in control group 2 was 75.00%,the adverse reactions occurred rate was 25.00%.There was statistical significance among the 3 groups （P〈0.05）. Conclusion For patients with UC cured by mesalazine combined with dichotomous sanlian living bacterium,which can significantly improve the clinical symptoms,reduce adverse reactions,and has good clinical effect,so can improve the quality life of patients,it is worthy of clinic application.